Osteoporosis International

, Volume 22, Issue 1, pp 69–73

Growth in childhood predicts hip fracture risk in later life

  • M. K. Javaid
  • J. G. Eriksson
  • E. Kajantie
  • T. Forsén
  • C. Osmond
  • D. J. P. Barker
  • C. Cooper
Original Article

DOI: 10.1007/s00198-010-1224-3

Cite this article as:
Javaid, M.K., Eriksson, J.G., Kajantie, E. et al. Osteoporos Int (2011) 22: 69. doi:10.1007/s00198-010-1224-3

Abstract

Summary

The incidence of hip fracture was estimated in 6,370 women born in Helsinki between 1934 and 1944. Women in the lowest quarter of adiposity gain had an 8.2-fold increase in hip fracture risk compared with those in the highest quarter (p < 0.001). These data point to a relationship between childhood growth and fracture risk during later life.

Introduction

Previous findings show that discordance between childhood increase in height and weight is associated with an increased risk of osteoporotic fractures during later life.

Methods

We studied 6,370 women born in Helsinki between 1934 and 1944. Each woman’s birth weight and length at birth was recorded, as well as her height and weight through childhood. We identified the occurrence of hip fracture through the National Finnish Hospital discharge register.

Results

There were 49 hip fractures in the 6,370 women over 187,238 person-years of follow-up. Hip fracture was associated with increasing Z-scores for height between 1 and 12 years, not matched by a corresponding increase in weight. Therefore, reduction in the Z-score for body mass index was associated with increased risk of hip fracture. Women in the lowest quarter of change in Z-scores for body mass index had an 8.2-fold increase in hip fracture risk (95% CI 1.9 to 35), compared with those in the highest quarter (p < 0.001).

Conclusion

Thinness in childhood is a risk factor for hip fracture in later life. This could be a direct effect of low fat mass on bone mineralization, or represent the influence of altered timing of pubertal maturation.

Keywords

Developmental origins Epidemiology Hip fracture Osteoporosis 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2010

Authors and Affiliations

  • M. K. Javaid
    • 1
    • 2
  • J. G. Eriksson
    • 3
    • 4
    • 5
    • 6
    • 7
  • E. Kajantie
    • 4
    • 8
  • T. Forsén
    • 9
  • C. Osmond
    • 1
  • D. J. P. Barker
    • 1
  • C. Cooper
    • 1
    • 2
  1. 1.MRC Epidemiology Resource Centre, Southampton General HospitalUniversity of SouthamptonSouthamptonUK
  2. 2.NIHR Musculoskeletal BRU, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal SciencesUniversity of OxfordOxfordUK
  3. 3.Department of General Practice and Primary Health CareUniversity of HelsinkiHelsingin yliopistoFinland
  4. 4.National Institute for Health and WelfareDepartment of Chronic Disease PreventionHelsinkiFinland
  5. 5.Vaasa Central Hospital, Sandviksgatan 2-4VaasaFinland
  6. 6.Folkhälsan Research CentreHelsinkiHelsingfors UniversitetFinland
  7. 7.Unit of General PracticeHelsinki University Central HospitalHUSFinland
  8. 8.Hospital for Children and AdolescentsHelsinki University Central HospitalHelsinkiFinland
  9. 9.Vaasa Health Care CentreVaasaFinland

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