Osteoporosis International

, Volume 22, Issue 1, pp 63–68

Severity of vertebral fracture and risk of hip fracture: a nested case–control study

  • V. Puisto
  • M. Heliövaara
  • O. Impivaara
  • T. Jalanko
  • H. Kröger
  • P. Knekt
  • A. Aromaa
  • H. Rissanen
  • I. Helenius
Original Article

DOI: 10.1007/s00198-010-1195-4

Cite this article as:
Puisto, V., Heliövaara, M., Impivaara, O. et al. Osteoporos Int (2011) 22: 63. doi:10.1007/s00198-010-1195-4

Abstract

Summary

Severe vertebral fractures strongly predicted subsequent hip fracture in this population-based study. Such high-risk patients should be provided with clinical evaluation and care for osteoporosis.

Introduction

Vertebral fractures are commonly osteoporotic and known to predict hip fracture. The aim of this study was to evaluate associations between the severity of vertebral fractures and the risk of subsequent hip fracture.

Methods

Chest radiographs were obtained of 7,095 Finnish men and women aged 30 years or over in the Mini-Finland Health Survey in 1978–1980. Record linkage to the National Hospital Discharge Register identified 182 subjects from the survey who had subsequently been hospitalized for primary treatment of hip fracture by the end of 1994. A nested case–control setting was adopted, where three controls individually matched for age, gender, and place of residence were drawn for 169 subjects with hip fracture from the same cohort. Baseline vertebral fractures were identified at levels T3 to T12, and their morphology was categorized to mild, moderate, or severe according to Genant's classification.

Results

Severe vertebral fracture (>40% reduction in vertebral body height) strongly predicted hip fracture. After controlling for education, physical activity, smoking, alcohol consumption, and self-rated general health, the adjusted relative odds was 12.06 (95% confidence interval, 3.80–38.26). Mild to moderate fracture grades and the number of compressed vertebral bodies showed no prediction for hip fracture.

Conclusions

The presence of a severe vertebral fracture in the thoracic spine strongly predicts subsequent hip fracture. Such high-risk patients should be clinically evaluated and provided with care for osteoporosis and measures to reduce the risk of falling as required.

Keywords

Epidemiological study Fracture risk Hip fracture Osteoporosis Vertebral fracture 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2010

Authors and Affiliations

  • V. Puisto
    • 1
    • 2
    • 3
    • 6
  • M. Heliövaara
    • 1
  • O. Impivaara
    • 1
  • T. Jalanko
    • 2
  • H. Kröger
    • 4
  • P. Knekt
    • 1
  • A. Aromaa
    • 1
  • H. Rissanen
    • 1
  • I. Helenius
    • 5
  1. 1.National Institute for Health and WelfareHelsinkiFinland
  2. 2.Hospital for Children and AdolescentsHelsinki University Central HospitalHelsinkiFinland
  3. 3.ORTON Orthopaedic HospitalInvalid FoundationHelsinkiFinland
  4. 4.Kuopio University HospitalKuopioFinland
  5. 5.Turku Children’s HospitalTurku University Central HospitalTurkuFinland
  6. 6.HelsinkiFinland

Personalised recommendations