Risk of subsequent fracture and mortality within 5 years after a non-vertebral fracture
The absolute 5-year risk of subsequent non-vertebral fractures (NVFs) in 1,921 patients presenting with a NVF was 17.6% and of mortality was 32.3%. These risks were highest within the first year, indicating the need to study which reversible factors can be targeted to immediately minimise subsequent fracture risk and mortality.
NVFs are the most frequent clinical fractures in patients presenting at the emergency unit because of a clinical fracture. The aim of the study was to determine the 5-year absolute risk (AR) of subsequent NVF and mortality in patients at the time they present with a NVF.
Between 1999 and 2001, 1,921 consecutive patients 50+ years from a level 1 trauma centre were included. All NVFs were confirmed on radiograph reports, and mortality was checked in the national obituary database. Available potential risk factors for a subsequent NVF and mortality (age, sex and baseline fracture location: major—hip, pelvis, multiple ribs, proximal tibia/humerus and distal femur; minor—all others) were expressed as hazard ratios (HR) with 95% confidence intervals (CI) using multivariable Cox regression analysis.
The AR for a subsequent NVF was 17.6% and was related to age (HR per decade, 1.44; 95%CI, 1.29–1.60). The AR for mortality was 32.3% and was related to age (HR per decade, 2.59; 95%CI, 2.37–2.84), male sex (HR, 1.74; 95%CI, 1.44–2.10), major fracture at baseline (HR, 5.56; 95%CI, 3.48–8.88; not constant over time) and subsequent fracture (HR, 1.65; 95%CI, 1.33–2.05). The highest risks were found within the first year (NVFs, 6.4%; mortality, 12.2%) and were related to age and, in addition, to baseline fracture location for mortality.
Within 5 years after an initial NVF, nearly one in five patients sustained a subsequent NVF and one in three died. One third of subsequent NVFs and mortality occurred within 1 year, indicating the need to study which reversible factors can be targeted to immediately prevent subsequent fractures and mortality.
- Risk of subsequent fracture and mortality within 5 years after a non-vertebral fracture
- Open Access
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Volume 21, Issue 12 , pp 2075-2082
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- Fracture incidence
- Fracture risk
- Non-vertebral fractures
- Industry Sectors
- Author Affiliations
- 1. Department of Trauma Surgery, Maastricht University Medical Centre, P. Debyelaan 25, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands
- 2. School for Public Health and Primary Care (CAPHRI), Maastricht, The Netherlands
- 3. Department of General Practice, Maastricht University Medical Centre, P.O. Box 616, 6200 MD, Maastricht, The Netherlands
- 4. Department of Internal Medicine/Rheumatology, Maastricht University Medical Centre, Maastricht, The Netherlands
- 5. Biomedical Research Institute, University Hasselt, Hasselt, Belgium
- 7. Department of Othopaedic Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands
- 6. KEMTA (Klinische Epidemiologie en Medical Technology Assessment), Maastricht, The Netherlands
- 8. Department of Methodology and Statistics, Maastricht University Medical Centre, Maastricht, The Netherlands