Osteoporosis International

, Volume 21, Issue 8, pp 1307–1316

Bone mineral density and prevalent osteoarthritis of the hip in older men for the Osteoporotic Fractures in Men (MrOS) Study Group

Authors

  • R. K. Chaganti
    • University of California at San Francisco
  • N. Parimi
    • California Pacific Medical Center Research Institute
  • T. Lang
    • University of California at San Francisco
  • E. Orwoll
    • Oregon Health Sciences University
  • M. L. Stefanick
    • Stanford Prevention Research Center, Department of MedicineStanford University
  • M. Nevitt
    • University of California at San Francisco
    • University of California at Davis Medical School
    • Department of MedicineUniversity of California at Davis School of Medicine
  • for the Osteoporotic Fractures in Men (MrOS) Study Group
Original Article

DOI: 10.1007/s00198-009-1105-9

Cite this article as:
Chaganti, R.K., Parimi, N., Lang, T. et al. Osteoporos Int (2010) 21: 1307. doi:10.1007/s00198-009-1105-9

Abstract

Summary

We evaluated the association of bone mineral density (BMD) and osteoarthritis (OA) of the hip in elderly men. We found that elderly men with moderate to severe radiographic hip OA (RHOA) had significantly higher areal BMD (aBMD) and volumetric BMD (vBMD) at both the lumbar spine and hip compared to age similar controls without OA.

Introduction

We evaluated the association of BMD measured by dual energy X-ray absorptiometry (DXA) and quantitative computerized tomography (integral, cortical, and trabecular vBMD) and RHOA in a cohort of elderly men.

Methods

A cross-sectional analysis was conducted within the Study of Osteoporotic Fractures in Men, a prospective cohort study of 5,995 US men age ≥ 65 years. Standing pelvic x-rays were done in 4,024 subjects and scored for prevalent RHOA severity. DXA was done in 3,886 subjects, and aBMD and vBMD associations were compared with RHOA score using linear regression, adjusting for covariates.

Results

Both moderate and severe RHOA groups had significantly higher aBMD at all BMD sites (range, 3.7–10.0% difference; p value 0.0012 and p value < 0.005) compared to the control group with no RHOA. The difference remained strong after adjusting for covariates. While the total hip and lumbar spine cortical vBMD measurements of subjects with moderate or severe RHOA was increased compared to controls, trabecular vBMD was not.

Conclusion

Older men, with both moderate and severe RHOA, had significantly higher aBMD and integral vBMD at the hip and lumbar spine compared to controls without RHOA.

Keyword

Hip osteoarthritis

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2010