Osteoporosis International

, Volume 20, Issue 8, pp 1401–1406

Bone mass and structure in adolescents with type 1 diabetes compared to healthy peers

  • M. T. Saha
  • H. Sievänen
  • M. K. Salo
  • S. Tulokas
  • H. H. Saha
Original Article

DOI: 10.1007/s00198-008-0810-0

Cite this article as:
Saha, M.T., Sievänen, H., Salo, M.K. et al. Osteoporos Int (2009) 20: 1401. doi:10.1007/s00198-008-0810-0

Abstract

Summary

We measured bone mass and structure using pQCT and DXA in adolescents with Type 1 diabetes and compared the results with those of healthy peers. Our results showed that diabetes is associated with reduced bone mass and smaller bones. The diabetes-associated deficits seemed to concern male adolescents more than females.

Introduction

The aim of this study was to compare bone mass and structure between adolescents with type 1 diabetes and their healthy peers.

Methods

Peripheral quantitative computed tomography (pQCT) at radius and tibia, and dual-energy X-ray absorptiometry (DXA) at lumbar spine and proximal femur were performed for 48 adolescents, 26 girls and 22 boys, with type 1 diabetes, and for healthy peers matched for age, sex, body height and weight, and pubertal maturity.

Results

Diabetes was associated with reduced bone mineral content (BMC) and smaller bone cross-sectional size. Diabetic boys seemed to be more affected than diabetic girls. Among the boys, the mean deficit in BMC of all measured skeletal sites was more than 10%, while among the girls it was less than 5%.

Conclusion

In conclusion, type 1 diabetes is associated with reduced BMC and appears to affect bone cross-sectional size and cortical rigidity. The diabetes-related skeletal deficits seemed to concern male adolescents more than females. Whether diabetes-related deficits would contribute to an increased risk of fractures in adulthood or later in life remains to be confirmed.

Keywords

AdolescenceBone fragilityBone mineral contentOsteoporosisType 1 diabetes

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2008

Authors and Affiliations

  • M. T. Saha
    • 1
    • 2
  • H. Sievänen
    • 2
    • 3
  • M. K. Salo
    • 1
  • S. Tulokas
    • 4
  • H. H. Saha
    • 2
    • 4
  1. 1.Department of PaediatricsTampere University HospitalTampereFinland
  2. 2.University of TampereTampereFinland
  3. 3.UKK Institute for Health Promotion ResearchTampereFinland
  4. 4.Department of Internal MedicineTampere University HospitalTampereFinland