Osteoporosis International

, Volume 20, Issue 8, pp 1337–1346

A reference database for the Stratec XCT-2000 peripheral quantitative computed tomography (pQCT) scanner in healthy children and young adults aged 6–19 years

  • R. L. Ashby
  • K. A. Ward
  • S. A. Roberts
  • L. Edwards
  • M. Z. Mughal
  • J. E. Adams
Original Article

DOI: 10.1007/s00198-008-0800-2

Cite this article as:
Ashby, R.L., Ward, K.A., Roberts, S.A. et al. Osteoporos Int (2009) 20: 1337. doi:10.1007/s00198-008-0800-2

Abstract

Summary

We have produced paediatric reference data for forearm sites using the Stratec XCT-2000 peripheral quantitative computed tomography scanner. These data are intended for clinical and research use and will assist in the interpretation of bone mineral density and bone geometric parameters at the distal and mid-shaft radius in children and young adults aged between 6–19 years.

Introduction

Peripheral quantitative computed tomography (pQCT) provides measurements of bone mineral content (BMC), density (BMD) and bone geometry. There is a lack of reference data available for the interpretation of pQCT measurements in children and young adults. The aim of this study was to provide reference data at the distal and mid-shaft radius.

Methods

pQCT was used to measure the 4% and 50% sites of the non-dominant radius in a cohort of healthy white Caucasian children and young adults aged between 5 and 25 years. The lambda, mu, sigma (LMS) technique was used to produce gender-specific reference centile curves and LMS tables for calculating individual standard deviations scores.

Results

The study population consisted of 629 participants (380 males). Reference centile curves were produced; total and trabecular BMD for age (distal radius) and for age and height, bone area (distal and mid-shaft radius), cortical area, cortical thickness, BMC, axial moment of inertia, stress–strain index and muscle area (mid-shaft radius).

Conclusions

We present gender-specific databases for the assessment of the distal and mid-shaft radius by pQCT. These data can be used as control data for research studies and allow the clinical interpretation of pQCT measurements in children and young adults by age and height.

Keywords

AdolescentBone densityBone developmentChildReference valuesTomographyX-ray computed

Supplementary material

198_2008_800_MOESM1_ESM.doc (154 kb)
ESM 1(153 KB DOC)
198_2008_800_MOESM2_ESM.pdf (6 mb)
ESM 2(6 MB PDF)

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2009

Authors and Affiliations

  • R. L. Ashby
    • 1
  • K. A. Ward
    • 1
  • S. A. Roberts
    • 2
  • L. Edwards
    • 1
    • 3
  • M. Z. Mughal
    • 4
  • J. E. Adams
    • 1
    • 5
  1. 1.Clinical Radiology, Imaging Science & Cancer Studies, Stopford BuildingUniversity of ManchesterManchesterUK
  2. 2.Biostatistics Group, School of Epidemiology and Health Sciences, Stopford BuildingUniversity of ManchesterManchesterUK
  3. 3.Faculty of Medicine, School of Health SciencesUniversity of LiverpoolLiverpoolUK
  4. 4.Department of Paediatric Medicine, Saint Mary’s Hospital for Women & ChildrenCentral Manchester & Manchester Children’s Hospitals NHS TrustManchesterUK
  5. 5.Clinical RadiologyManchester Royal InfirmaryManchesterUK