Effect of alendronate in elderly patients after low trauma hip fracture repair

  • D. Cecilia
  • E. Jódar
  • C. Fernández
  • C. Resines
  • F. Hawkins
Original Article

DOI: 10.1007/s00198-008-0767-z

Cite this article as:
Cecilia, D., Jódar, E., Fernández, C. et al. Osteoporos Int (2009) 20: 903. doi:10.1007/s00198-008-0767-z

Abstract

Summary

One year of once weekly alendronate, when given shortly after the surgical repair of a hip fracture, produces reductions in bone markers and increases proximal femoral bone density. The therapy was well tolerated.

Introduction

Hip fracture is the most devastating type of osteoporotic fracture and increases notably the risk of subsequent fractures. The aim of this paper was to evaluate the effects of 1 year therapy with a weekly dose of alendronate in the bone mineral density and bone markers in elderly patients after low trauma hip fracture repair.

Methods

Two hundred thirty-nine patients (81 ± 7 years; 79.8% women) were randomized to be treated either with calcium (500 mg/daily) and vitamin D3 (400 IU/daily; Ca–Vit D group) or with alendronate (ALN, 70 mg/week) plus calcium and vitamin D3 (500 mg/daily and 400 IU/daily, respectively; ALN + Ca–Vit D group).

Results

One hundred forty-seven (61.5%) patients completed the trial. Alendronate increased proximal femoral bone mineral density (BMD) in the intention-to-treat analysis (mean difference (95% confidence interval); total hip 2.57% (0.67; 4.47); trochanteric 2.96% (0.71; 5.20), intertrochanteric 2.32% (0.36; 4.29)), but the differences were not significant in the BMD of the femoral neck (0.47%; (−2.03; 2.96) and the lumbar spine (0.69%; (−0.86; 2.23)). Bone turnover markers decreased during alendronate treatment.

Conclusion

The present study demonstrates for the first time the anti-resorptive efficacy of alendronate given immediately after surgical repair in an elderly population with recent hip fracture. This effect should positively affect the rate of subsequent fractures.

Keywords

Alendronate Bone markers Bone mineral density Elderly Hip fracture surgically treated 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2008

Authors and Affiliations

  • D. Cecilia
    • 1
  • E. Jódar
    • 2
    • 4
  • C. Fernández
    • 3
  • C. Resines
    • 1
  • F. Hawkins
    • 2
  1. 1.Traumatology and Orthopedic SurgeryUniversity Hospital “12 de Octubre”MadridSpain
  2. 2.Endocrinology and Metabolism ServicesUniversity Hospital “12 de Octubre”MadridSpain
  3. 3.Preventive Medicine ServiceUniversity Hospital “San Carlos”, Complutense UniversityMadridSpain
  4. 4.Servicio de Endocrinología y NutriciónHospital Universitario “12 de Octubre”MadridSpain

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