Osteoporosis International

, 20:463

Design of the POSSIBLE US™ Study: postmenopausal women’s compliance and persistence with osteoporosis medications

  • E. Barrett-Connor
  • K. Ensrud
  • A. N. A. Tosteson
  • S. F. Varon
  • M. Anthony
  • N. Daizadeh
  • S. Wade
Original Article

DOI: 10.1007/s00198-008-0674-3

Cite this article as:
Barrett-Connor, E., Ensrud, K., Tosteson, A.N.A. et al. Osteoporos Int (2009) 20: 463. doi:10.1007/s00198-008-0674-3

Abstract

Summary

Failure to take prescribed medication is common. The POSSIBLE US™ study is evaluating the impact of physician and patient characteristics on patient-reported compliance and persistence with osteoporosis medications. We report our study design and the baseline characteristics of 4,994 postmenopausal women recruited from primary care physician offices in 33 states.

Introduction

The Prospective Observational Scientific Study Investigating Bone Loss Experience (POSSIBLE US™) is a longitudinal cohort study of osteoporosis therapy in primary care.

Methods

Between 2004 and 2007, 134 physicians (in 33 states) enrolled postmenopausal women initiating, changing, or continuing osteoporosis medications. After completing a baseline questionnaire, participants will provide data semi-annually for up to 3 years through 2008. Physicians provide patient data at baseline and routine follow-up visits. Participants from 23 sites also signed a release regarding administrative claims data for economic analyses and validation of self-reported data.

Baseline results

Four thousand nine hundred and ninety-four evaluable women were recruited from internal medicine (n = 1,784), family practice (n = 1,556), obstetrics/gynecology (n = 1,556), and from one rheumatology practice (n = 98). Mean participant age was 64.3 years (SD = 9.97); 89% were Caucasian; 59% had some college education. Sixty-three percent used a single osteoporosis agent, usually a bisphosphonate. For monotherapy patients, concordance between clinic- and patient-reported medication use was lowest for patients prescribed estrogen therapy (70%) or calcium/vitamin D (72%). Obstetrician/gynecologists enrolled younger women, who were more likely to use estrogen therapy than patients enrolled by other physicians. The 934 women (19%) prescribed only calcium/vitamin D were younger than women prescribed pharmacologic therapy.

Conclusions

POSSIBLE US™ provides a unique foundation for evaluating longitudinal use of osteoporosis medications and related outcomes.

Keywords

Cohort studies Compliance Osteoporosis Postmenopausal osteoporosis Prospective studies 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2008

Authors and Affiliations

  • E. Barrett-Connor
    • 1
  • K. Ensrud
    • 2
  • A. N. A. Tosteson
    • 3
  • S. F. Varon
    • 4
  • M. Anthony
    • 4
  • N. Daizadeh
    • 4
  • S. Wade
    • 5
  1. 1.Division of Epidemiology, Department of Family and Preventive Medicine, School of MedicineUniversity of California, San DiegoLa JollaUSA
  2. 2.University of MinnesotaMinneapolisUSA
  3. 3.Dartmouth Medical SchoolHanoverUSA
  4. 4.Amgen, Inc.Thousand OaksUSA
  5. 5.Wade Outcomes Research and ConsultingSalt Lake CityUSA