Osteoporosis International

, Volume 20, Issue 2, pp 275–282

The prevalence of radiographic vertebral fractures in Latin American countries: the Latin American Vertebral Osteoporosis Study (LAVOS)

  • P. Clark
  • F. Cons-Molina
  • M. Deleze
  • S. Ragi
  • L. Haddock
  • J. R. Zanchetta
  • J. J. Jaller
  • L. Palermo
  • J. O. Talavera
  • D. O. Messina
  • J. Morales-Torres
  • J. Salmeron
  • A. Navarrete
  • E. Suarez
  • C. M. Pérez
  • S. R. Cummings
Original Article

DOI: 10.1007/s00198-008-0657-4

Cite this article as:
Clark, P., Cons-Molina, F., Deleze, M. et al. Osteoporos Int (2009) 20: 275. doi:10.1007/s00198-008-0657-4

Abstract

Summary

In the first population-based study of vertebral fractures in Latin America, we found a 11.18 (95% CI 9.23–13.4) prevalence of radiographically ascertained vertebral fractures in a random sample of 1,922 women from cities within five different countries. These figures are similar to findings from studies in Beijing, China, some regions of Europe, and slightly lower than those found in the USA using the same standardized methodology.

Introduction

We report the first study of radiographic vertebral fractures in Latin America.

Methods

An age-stratified random sample of 1,922 women aged 50 years and older from Argentina, Brazil, Colombia, Mexico, and Puerto Rico were included. In all cases a standardized questionnaire and lateral X-rays of the lumbar and thoracic spine were obtained after informed consent.

Results

A standardized prevalence of 11.18 (95% CI 9.23–13.4) was found. The prevalence was similar in all five countries, increasing from 6.9% (95% CI 4.6–9.1) in women aged 50–59 years to 27.8% (95% CI 23.1–32.4) in those 80 years and older (p for trend < 0.001). Among different risk factors, self-reported height loss OR = 1.63 (95% CI: 1.18–2.25), and previous history of fracture OR = 1.52 (95% CI: 1.14–2.03) were significantly (p < 0.003 and p < 0.04 respectably) associated with the presence of radiographic vertebral fractures in the multivariate analysis. In the bivariate analyses HRT was associated with a 35% lower risk OR = 0.65 (95% CI: 0.46–0.93) and physical activity with a 27% lower risk of having a vertebral fracture OR = 0.73 (95% CI: 0.55–0.98), but were not statistically significant in multivariate analyses

Conclusion

We conclude that radiographically ascertained vertebral fractures are common in Latin America. Health authorities in the region should be aware and consider implementing measures to prevent vertebral fractures.

Keywords

EpidemiologyLatin AmericaOsteoporosisPrevalenceVertebral fractures

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2008

Authors and Affiliations

  • P. Clark
    • 1
  • F. Cons-Molina
    • 2
  • M. Deleze
    • 3
  • S. Ragi
    • 4
  • L. Haddock
    • 5
  • J. R. Zanchetta
    • 6
  • J. J. Jaller
    • 7
  • L. Palermo
    • 8
  • J. O. Talavera
    • 9
  • D. O. Messina
    • 10
  • J. Morales-Torres
    • 11
  • J. Salmeron
    • 12
  • A. Navarrete
    • 13
  • E. Suarez
    • 14
  • C. M. Pérez
    • 14
  • S. R. Cummings
    • 15
  1. 1.Clinical Epidemiology Unit, CMN Siglo XXIIMSS Faculty of Medicine UNAMLomas de ChapultepecMexico CityMexico
  2. 2.Unidad de Diagnostico de OsteoporosisMexicaliMexico
  3. 3.Hospital Los AngelesPueblaMexico
  4. 4.CEDOES Diagnóstico e Pesquisa Vitória (ES)Rio PiedrasBrazil
  5. 5.Division of Endocrinology, Diabetes and Metabolism, Department of MedicineUniversity of Puerto RicoSan JuanPuerto Rico
  6. 6.Facultad de Medicina Universidad del SalvadorInstituto de Investigaciones MetabólicasBuenos AiresArgentina
  7. 7.Internal Medicine DepartmentHospital Metropolitano Faculty of Medicine Universidad LibreBarranquillaColombia
  8. 8.Department Epidemiology and BiostatisticsUniversity of CaliforniaSan FranciscoUSA
  9. 9.Clinical Epidemiology Unit CMN Siglo XXI-IMSS, Centro de Investigación en Ciencias MédicasUAEMéxMexico CityMexico
  10. 10.Director Rheumatology DepartmentCosme Argerich Hospital and CIRO Medical Center. School of MedicineBuenos AiresArgentina
  11. 11.Osteoporosis UnitHospital Aranda de la ParraLeónMexico
  12. 12.Unidad de Investigación Epidemiológica y en Servicios de Salud, Cuernavaca MorelosInstituto Mexicano del Seguro SocialMexico CityMexico
  13. 13.Hospital General de Zona Numero 15, Instituto Mexicano del Seguro SocialReynosa Tamaulipas MéxicoReynosaMexico
  14. 14.Department of Biostatistics and Epidemiology, Graduate School of Public HealthUniversity of Puerto RicoSan JuanPuerto Rico
  15. 15.San Francisco Coordinating CenterCalifornia Pacific Medical Center Research Institute and University of CaliforniaSan FranciscoUSA