Original Article

Osteoporosis International

, Volume 20, Issue 2, pp 275-282

The prevalence of radiographic vertebral fractures in Latin American countries: the Latin American Vertebral Osteoporosis Study (LAVOS)

  • P. ClarkAffiliated withClinical Epidemiology Unit, CMN Siglo XXI, IMSS Faculty of Medicine UNAM Email author 
  • , F. Cons-MolinaAffiliated withUnidad de Diagnostico de Osteoporosis
  • , M. DelezeAffiliated withHospital Los Angeles
  • , S. RagiAffiliated withCEDOES Diagnóstico e Pesquisa Vitória (ES)
  • , L. HaddockAffiliated withDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Puerto Rico
  • , J. R. ZanchettaAffiliated withFacultad de Medicina Universidad del Salvador, Instituto de Investigaciones Metabólicas
  • , J. J. JallerAffiliated withInternal Medicine Department, Hospital Metropolitano Faculty of Medicine Universidad Libre
  • , L. PalermoAffiliated withDepartment Epidemiology and Biostatistics, University of California
  • , J. O. TalaveraAffiliated withClinical Epidemiology Unit CMN Siglo XXI-IMSS, Centro de Investigación en Ciencias Médicas, UAEMéx
    • , D. O. MessinaAffiliated withClinical Epidemiology Unit, CMN Siglo XXI, IMSS Faculty of Medicine UNAMDirector Rheumatology Department, Cosme Argerich Hospital and CIRO Medical Center. School of Medicine
    • , J. Morales-TorresAffiliated withClinical Epidemiology Unit, CMN Siglo XXI, IMSS Faculty of Medicine UNAMOsteoporosis Unit, Hospital Aranda de la Parra
    • , J. SalmeronAffiliated withClinical Epidemiology Unit, CMN Siglo XXI, IMSS Faculty of Medicine UNAMUnidad de Investigación Epidemiológica y en Servicios de Salud, Cuernavaca Morelos, Instituto Mexicano del Seguro Social
    • , A. NavarreteAffiliated withClinical Epidemiology Unit, CMN Siglo XXI, IMSS Faculty of Medicine UNAMHospital General de Zona Numero 15, Instituto Mexicano del Seguro Social, Reynosa Tamaulipas México
    • , E. SuarezAffiliated withClinical Epidemiology Unit, CMN Siglo XXI, IMSS Faculty of Medicine UNAMDepartment of Biostatistics and Epidemiology, Graduate School of Public Health, University of Puerto Rico
    • , C. M. PérezAffiliated withClinical Epidemiology Unit, CMN Siglo XXI, IMSS Faculty of Medicine UNAMDepartment of Biostatistics and Epidemiology, Graduate School of Public Health, University of Puerto Rico
    • , S. R. CummingsAffiliated withClinical Epidemiology Unit, CMN Siglo XXI, IMSS Faculty of Medicine UNAMSan Francisco Coordinating Center, California Pacific Medical Center Research Institute and University of California

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Summary

In the first population-based study of vertebral fractures in Latin America, we found a 11.18 (95% CI 9.23–13.4) prevalence of radiographically ascertained vertebral fractures in a random sample of 1,922 women from cities within five different countries. These figures are similar to findings from studies in Beijing, China, some regions of Europe, and slightly lower than those found in the USA using the same standardized methodology.

Introduction

We report the first study of radiographic vertebral fractures in Latin America.

Methods

An age-stratified random sample of 1,922 women aged 50 years and older from Argentina, Brazil, Colombia, Mexico, and Puerto Rico were included. In all cases a standardized questionnaire and lateral X-rays of the lumbar and thoracic spine were obtained after informed consent.

Results

A standardized prevalence of 11.18 (95% CI 9.23–13.4) was found. The prevalence was similar in all five countries, increasing from 6.9% (95% CI 4.6–9.1) in women aged 50–59 years to 27.8% (95% CI 23.1–32.4) in those 80 years and older (p for trend < 0.001). Among different risk factors, self-reported height loss OR = 1.63 (95% CI: 1.18–2.25), and previous history of fracture OR = 1.52 (95% CI: 1.14–2.03) were significantly (p < 0.003 and p < 0.04 respectably) associated with the presence of radiographic vertebral fractures in the multivariate analysis. In the bivariate analyses HRT was associated with a 35% lower risk OR = 0.65 (95% CI: 0.46–0.93) and physical activity with a 27% lower risk of having a vertebral fracture OR = 0.73 (95% CI: 0.55–0.98), but were not statistically significant in multivariate analyses

Conclusion

We conclude that radiographically ascertained vertebral fractures are common in Latin America. Health authorities in the region should be aware and consider implementing measures to prevent vertebral fractures.

Keywords

Epidemiology Latin America Osteoporosis Prevalence Vertebral fractures