Osteoporosis International

, Volume 19, Issue 11, pp 1579–1587

Age-and region-dependent changes in three-dimensional microstructural properties of proximal femoral trabeculae

Authors

  • W.-Q. Cui
    • Department of Orthopaedic SurgeryAjou University School of Medicine
    • Department of Orthopaedic SurgeryAjou University School of Medicine
  • M.-H. Baek
    • Department of Orthopaedic SurgeryAjou University School of Medicine
  • D.-H. Lee
    • Department of Orthopaedic SurgeryAjou University School of Medicine
  • Y.-S. Chung
    • Endocrinology and MetabolismAjou University School of Medicine
  • J.-H. Hur
    • Orthopaedic SurgeryOrthopaedic Specialty Hospital
  • Y.-Z. Ma
    • Orthopaedic Surgery, The Second Affiliated HospitalPeople’s Liberation Army General Hospital
Original Article

DOI: 10.1007/s00198-008-0601-7

Cite this article as:
Cui, W., Won, Y., Baek, M. et al. Osteoporos Int (2008) 19: 1579. doi:10.1007/s00198-008-0601-7

Abstract

Summary

This study investigated regional variations in the 3D microstructure of trabecular bone in human proximal femur, with respect to aging. The results demonstrate that age-related changes in trabecular microstructure significantly varied from different sub-regions of the proximal femur.

Introduction

We hypothesize that the age-related changes in trabecular bone microstructure appear to be varied from specific anatomic sub-regions of the proximal femur followed by non-uniform bone loss. The purpose of this study was therefore to explore regional variations in the 3D microstructure of trabecular bone in human proximal femur, with respect to aging.

Methods

A total of 162 trabecular bone cores from six regions of 27 femora of male cadaver donors were scanned using micro-computed tomography (micro-CT). The following microstructural parameters were calculated: bone volume fraction (BV/TV), trabecular number (Tb.N), thickness (Tb.Th) and separation (Tb.Sp), structure model index (SMI), and degree of anisotropy (DOA).

Results

Age-related changes in trabecular microstructure varied from different regions of the proximal femur. There was a significant decrease in bone volume fraction and an almost identical decrease in trabecular thickness associated with aging at any region. Regional analysis demonstrated a significant difference in BV/TV, Tb.Th, Tb.Sp, Tb.N and DOA between superior and inferior neck, as well as a significant difference in BV/TV, Tb.Sp, Tb.N, SMI and DOA between superior and inferior trochanter.

Conclusions

Age-related changes in bone loss and trabecular microstructure within the male proximal femur are not uniform in this cadaveric population.

Keywords

AgingMicrostructureProximal femurTrabeculae

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2008