Original Article

Osteoporosis International

, Volume 19, Issue 11, pp 1579-1587

First online:

Age-and region-dependent changes in three-dimensional microstructural properties of proximal femoral trabeculae

  • W.-Q. CuiAffiliated withDepartment of Orthopaedic Surgery, Ajou University School of Medicine
  • , Y.-Y. WonAffiliated withDepartment of Orthopaedic Surgery, Ajou University School of Medicine Email author 
  • , M.-H. BaekAffiliated withDepartment of Orthopaedic Surgery, Ajou University School of Medicine
  • , D.-H. LeeAffiliated withDepartment of Orthopaedic Surgery, Ajou University School of Medicine
  • , Y.-S. ChungAffiliated withEndocrinology and Metabolism, Ajou University School of Medicine
  • , J.-H. HurAffiliated withOrthopaedic Surgery, Orthopaedic Specialty Hospital
  • , Y.-Z. MaAffiliated withOrthopaedic Surgery, The Second Affiliated Hospital, People’s Liberation Army General Hospital

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Abstract

Summary

This study investigated regional variations in the 3D microstructure of trabecular bone in human proximal femur, with respect to aging. The results demonstrate that age-related changes in trabecular microstructure significantly varied from different sub-regions of the proximal femur.

Introduction

We hypothesize that the age-related changes in trabecular bone microstructure appear to be varied from specific anatomic sub-regions of the proximal femur followed by non-uniform bone loss. The purpose of this study was therefore to explore regional variations in the 3D microstructure of trabecular bone in human proximal femur, with respect to aging.

Methods

A total of 162 trabecular bone cores from six regions of 27 femora of male cadaver donors were scanned using micro-computed tomography (micro-CT). The following microstructural parameters were calculated: bone volume fraction (BV/TV), trabecular number (Tb.N), thickness (Tb.Th) and separation (Tb.Sp), structure model index (SMI), and degree of anisotropy (DOA).

Results

Age-related changes in trabecular microstructure varied from different regions of the proximal femur. There was a significant decrease in bone volume fraction and an almost identical decrease in trabecular thickness associated with aging at any region. Regional analysis demonstrated a significant difference in BV/TV, Tb.Th, Tb.Sp, Tb.N and DOA between superior and inferior neck, as well as a significant difference in BV/TV, Tb.Sp, Tb.N, SMI and DOA between superior and inferior trochanter.

Conclusions

Age-related changes in bone loss and trabecular microstructure within the male proximal femur are not uniform in this cadaveric population.

Keywords

Aging Microstructure Proximal femur Trabeculae