Impact of compliance and persistence with bisphosphonate therapy on health care costs and utilization
- J. A. SunyeczAffiliated withLaurel Highlands Ob/Gyn, PC Email author
- , L. MuchaAffiliated withOutcomes Research and Econometrics
- , O. BaserAffiliated withThomson HealthcareUniversity of Michigan Medical School
- , C. E. BarrAffiliated withRoche
- , M. M. AmonkarAffiliated withGlaxoSmithKline
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The impact of persistence and compliance with bisphosphonate therapy on health care costs and utilization was examined in women newly prescribed bisphosphonates. At 3 years, women who were persistent and compliant with bisphosphonate therapy had lower total costs compared with non-persistent and non-compliant women, after controlling for relevant risk factors.
The impact of persistence and compliance with bisphosphonate therapy on health care costs and utilization was examined in bisphosphonate-naïve women.
Two claims databases were used to identify women ≥45 years of age and who filled a new bisphosphonate prescription during 2000–2002. Persistence and compliance were evaluated over 3 years. Compliance was defined as a medication possession ratio (days of bisphosphonate supply/days of follow-up) ≥0.80; persistence was defined as no refill gaps ≥30 days. Multivariate models accounted for potential confounders.
This analysis included 32,944 women (mean age, 64 years) who filled a new prescription for daily or weekly alendronate (n = 26,581) or risedronate (n = 6,363). At 3 years, 37% of women were compliant and 21% of women were persistent. Unadjusted total mean health care costs were lower for the compliant vs. non-compliant and persistent vs. non-persistent cohorts. After adjusting for potential confounders, total health care costs were reduced by 8.9% for persistent patients (p < 0.001) and 3.5% for compliant patients (p = 0.014). Persistence decreased the likelihood of inpatient admission by 47%.
At 3 years, women who were persistent and compliant with bisphosphonate therapy had lower total costs compared with non-persistent and non-compliant women, after controlling for relevant risk factors.
KeywordsBisphosphonates Compliance Cost Osteoporosis Persistence
- Impact of compliance and persistence with bisphosphonate therapy on health care costs and utilization
Volume 19, Issue 10 , pp 1421-1429
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- 1. Laurel Highlands Ob/Gyn, PC, 1142 National Pike Road, Hopwood, PA, 15445, USA
- 2. Outcomes Research and Econometrics, Cambridge, MA, USA
- 3. Thomson Healthcare, Ann Arbor, MI, USA
- 6. University of Michigan Medical School, Ann Arbor, MI, USA
- 4. Roche, Nutley, NJ, USA
- 5. GlaxoSmithKline, Collegeville, PA, USA