Osteoporosis International

, Volume 19, Issue 4, pp 503–510

Strontium ranelate prevents quality of life impairment in post-menopausal women with established vertebral osteoporosis

  • P. Marquis
  • C. Roux
  • C. de la Loge
  • M. Diaz-Curiel
  • C. Cormier
  • G. Isaia
  • J. Badurski
  • J. Wark
  • P. J. Meunier
Original Article

DOI: 10.1007/s00198-007-0464-3

Cite this article as:
Marquis, P., Roux, C., de la Loge, C. et al. Osteoporos Int (2008) 19: 503. doi:10.1007/s00198-007-0464-3

Abstract

Summary

Strontium ranelate reduces the risk of fracture in post-menopausal osteoporotic women with prevalent fractures for whom quality of life is severely impaired. The SOTI study, which used the SF-36® questionnaire and disease-specific QUALIOST® module, demonstrated that treatment with strontium ranelate improved osteoporotic women’s quality of life compared with placebo.

Introduction

The Spinal Osteoporosis Therapeutic Intervention (SOTI) study demonstrated the effect of orally administered strontium ranelate versus placebo on the incidence of new vertebral fractures and compared impact on quality of life (QoL).

Methods

QoL was assessed 6 monthly over 3 years using the QUALIOST® and SF-36® questionnaires in post-menopausal osteoporotic women with prevalent fracture taking strontium ranelate or placebo 2 g/day. A total of 1,240 women were included (strontium ranelate: n = 618 and placebo: n = 622).

Results

The QUALIOST® total score decreased in the strontium ranelate group, indicating preserved QoL compared with a deterioration in the placebo group (P = 0.016). Strontium ranelate patients had reduced QUALIOST® emotional and physical dimension scores (P = 0.019 and 0.032, respectively, versus placebo), indicating beneficial effects on emotional and physical functioning. There was a trend towards better SF-36® scores in the strontium ranelate group, although there were no significant between-group differences. More strontium ranelate patients (+ 31%) were free from back pain over 3 years versus placebo (P = 0.005), with a significant effect from the first year of treatment (P = 0.023).

Conclusion

Strontium ranelate has beneficial effects on QoL in women with post-menopausal osteoporosis compared with placebo.

Keywords

FracturesOsteoporosisQuality of lifeQUALIOST® SF-36®Strontium ranelate

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2007

Authors and Affiliations

  • P. Marquis
    • 1
  • C. Roux
    • 2
  • C. de la Loge
    • 3
  • M. Diaz-Curiel
    • 4
  • C. Cormier
    • 5
  • G. Isaia
    • 6
  • J. Badurski
    • 7
  • J. Wark
    • 8
  • P. J. Meunier
    • 9
  1. 1.Mapi ValuesBostonUSA
  2. 2.Service de Rhumatologie B, Hôpital CochinParisFrance
  3. 3.Mapi ValuesLyonFrance
  4. 4.Jimenez Diaz FoundationMadridSpain
  5. 5.Service de Rhumatologie A, Hôpital CochinParisFrance
  6. 6.Dipartimento di Medicina Interna Università di TorinoTorinoItaly
  7. 7.Polish Center of OsteoporosisBialystokPoland
  8. 8.Royal Melbourne HospitalParkville VicAustralia
  9. 9.Faculté LaënnecLyonFrance