Osteoporosis International

, Volume 18, Issue 12, pp 1661–1667

Dietary protein intake and bone mineral content in adolescents—The Copenhagen Cohort Study

  • A. Z. Budek
  • C. Hoppe
  • H. Ingstrup
  • K. F. Michaelsen
  • S. Bügel
  • C. Mølgaard
Original Article

DOI: 10.1007/s00198-007-0422-0

Cite this article as:
Budek, A.Z., Hoppe, C., Ingstrup, H. et al. Osteoporos Int (2007) 18: 1661. doi:10.1007/s00198-007-0422-0

Abstract

Summary

Data indicate that various protein sources may exhibit a differential effect on bone metabolism. We investigated associations of milk and meat protein intake with bone mineral content (BMC) in adolescents. Milk, but not meat, protein intake was positively associated with size-adjusted BMC. Milk-derived protein may be beneficial for bone mineralization.

Introduction

Milk and meat protein intake has been reported to exhibit a differential effect on serum insulin-like growth factor-I (IGF-I). IGF-I plays a key role in bone metabolism. Therefore, we investigated associations of different protein sources with BMC and bone area (BA) in adolescents.

Methods

This was a cross-sectional study of 17-year-old girls (n = 63) and boys (n = 46) participating in the second follow-up of The Copenhagen Cohort Study. We measured dietary intake (7-day food record), BMC and BA (dual-energy X-ray absorptiometry), serum markers for bone turnover and serum IGF-I (immunoassays).

Results

The mean total protein intake (∼1.2 g/kg) was modestly higher than that recommended. Total and milk (∼0.3 g/kg) protein intake, but not meat protein intake (∼0.4 g/kg), was positively associated with size-adjusted BMC (P ≤ 0.05). The positive association between milk protein intake and size-adjusted BMC remained significant after correction for energy, calcium, and physical activity (P ≤ 0.01) and did not seem to be mediated via current serum IGF-I. None of the analyzed protein sources was significantly associated with size-adjusted BA.

Conclusions

Our results suggest that some components of milk protein may promote bone mineralization. Further studies are needed to elucidate this phenomenon.

Keywords

BMCDietGrowthMeat proteinMilk protein

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2007

Authors and Affiliations

  • A. Z. Budek
    • 1
  • C. Hoppe
    • 1
  • H. Ingstrup
    • 1
  • K. F. Michaelsen
    • 1
  • S. Bügel
    • 1
  • C. Mølgaard
    • 1
  1. 1.Department of Human Nutrition, Faculty of Life SciencesUniversity of CopenhagenFrederiksbergDenmark