, Volume 18, Issue 9, pp 1253-1259
Date: 30 Mar 2007

Adiponectin is a predictor of bone mineral density in middle-aged premenopausal women

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Adipose-modulated biochemical signal that explains some of the association between fat mass and bone mineral density (BMD) is adiponectin. The results demonstrated an independent association between adiponectin and BMD, while the influence of adiponectin on bone mineral content is mediated by fat free mass in middle-aged women.


Positive association between fat mass (FM) and bone mineral density (BMD) is mediated by biochemical factors.


The relationship between plasma adiponectin concentration and BMD in 98 sedentary premenopausal women aged 38–49 years with a body mass index range of 20.0–42.1 kg/m2 was examined. Different body composition and blood biochemical parameters were measured to adjust for possible confounding variables.


The association between adiponectin and BMD values (total BMD: ß = −0.919; p = 0.0001, femoral neck BMD: ß = −0.925; p = 0.0001 and lumbar spine BMD: ß = −0.912; p = 0.0001) was independent of the influences that measured body composition, hormonal and insulin resistance factors may exert on BMD (p < 0.02). However, adiponectin explained only 3–12% of the variations in measured BMD variables. Similarly, adiponectin was associated with total bone mineral content (BMC; ß = −0.911; p = 0.0001) and remained associated in different analyses that controlled for possible confounding parameters (p < 0.01). However, the association between adiponectin and total BMC was no longer significant when adjusted for fat free mass (FFM; p > 0.21).


Adiponectin is an independent predictor of BMD, while its independent contribution to the interindividual variance in measured values is only modest. The influence of adiponectin on total BMC is mediated or confounded by FFM in middle-aged premenopausal women.