Osteoporosis International

, Volume 18, Issue 3, pp 295–305

Association of estrogen receptor α gene polymorphisms with bone mineral density in Chinese women: a meta-analysis

Original Article

DOI: 10.1007/s00198-006-0239-2

Cite this article as:
Wang, CL., Tang, XY., Chen, WQ. et al. Osteoporos Int (2007) 18: 295. doi:10.1007/s00198-006-0239-2


Introduction and hypothesis

A large number studies have examined the association between estrogen receptor alpha (ESR-α) gene polymorphisms and bone mineral density (BMD) in the Chinese population. We conducted a meta-analysis to assess their pooled effects.


We searched for all published articles indexed in MEDLINE, the Chinese Biomedical Database, and the Chinese Journal Full-text Database from January 1994 to April 2006. Any cross-sectional study that tested the association between ESR-α PvuII or XbaI genotypes and BMD at the femoral neck or spine in Chinese women was included in the review. Data were extracted independently by two reviewers using a standardized data extraction form. Sixteen eligible studies involving 4,297 Chinese women were identified.


The overall frequencies of X and P alleles were 28% and 40%, respectively. The PvuII polymorphism was statistically significantly associated with BMD at the femoral neck (P = 0.038 for PP = Pp = pp) but not at the lumbar spine in all women. The BMD difference for the contrasts of PP versus Pp/pp genotypes was −0.0105 (95%CI, −0.0202 ∼ −0.0008) g/cm2 (P = 0.036). The XbaI polymorphism was not associated with BMD at the femoral neck or lumbar spine.


The PvuII polymorphism had a very weak association with femoral neck BMD whereas XbaI polymorphism was unlikely to be a predictor of femoral neck or spine BMD in Chinese women.


Bone mineral densityChinese womenEstrogen receptor alpha geneGene polymorphismMeta-analysis

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2006

Authors and Affiliations

  1. 1.Department of Medical Statistics and Epidemiology, School of Public HealthSun Yat-sen UniversityGuangzhouPeople’s Republic of China
  2. 2.Department of Pediatrics, The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouPeople’s Republic of China
  3. 3.Department of Nutrition, School of Public HealthSun Yat-sen UniversityGuangzhouPeople’s Republic of China