Osteoporosis International

, Volume 18, Issue 3, pp 271–277

Compliance with osteoporosis drug therapy and risk of fracture

Original Article

DOI: 10.1007/s00198-006-0230-y

Cite this article as:
Weycker, D., Macarios, D., Edelsberg, J. et al. Osteoporos Int (2007) 18: 271. doi:10.1007/s00198-006-0230-y



Patient compliance with osteoporosis drug therapy is often poor in clinical practice and may be associated with higher risk of fracture.


A nested case-control study was undertaken using a US health insurance claims database. The source population included all women aged ≥45 years who began drug therapy for osteoporosis. Cases consisted of those who experienced an osteoporosis-related fracture; they were matched to controls without osteoporosis-related fracture. Compliance with osteoporosis drug treatment was assessed in terms of the number of therapy-days received and medication possession ratio (MPR). Conditional logistic regression was employed to examine the relationship between compliance and fracture risk.


A total of 453 women with osteoporosis-related fracture were identified and matched to 2,160 controls. Fracture risk was significantly lower for patients with >180 days of therapy [181–360 days: odds ratio (OR) = 0.70, 95% CI = 0.49–0.99; >360 days: OR = 0.65, 95% CI = 0.43–0.99) versus those with ≤30 days. Risk was also lower for patients with MPR ≥90% (OR = 0.70, 95% CI = 0.52–0.93) versus those with MPR <30%. Fracture risk decreased as compliance increased (ptrend < 0.05).


Among women initiating drug therapy for osteoporosis, better compliance is associated with reduced risk of fracture.



Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2006

Authors and Affiliations

  • D. Weycker
    • 1
  • D. Macarios
    • 2
  • J. Edelsberg
    • 1
  • G. Oster
    • 1
  1. 1.Policy Analysis Inc. (PAI)Four Davis CourtBrooklineUSA
  2. 2.Amgen, Inc.Thousand OaksUSA