Integrated anti-remodeling and anabolic therapy for the osteoporosis of Hajdu–Cheney syndrome
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- McKiernan, F.E. Osteoporos Int (2007) 18: 245. doi:10.1007/s00198-006-0221-z
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Hajdu–Cheney syndrome (MIM 102500) is a rare skeletal dysplasia marked by severe generalized osteoporosis and focal bone loss (acro-osteolysis). Osteoporosis treatment outcome has been reported only once previously. Reported herein is the biochemical and densitometric response to integrated anti-remodeling and anabolic therapy in a woman with Hajdu–Cheney syndrome. Results suggest dissociation of bone formation from bone resorption resulting in dramatic increases in bone mineral density without clinical evidence of activated osteoporosis.