Original Article

Osteoporosis International

, Volume 16, Issue 12, pp 1917-1923

First online:

Familial aggregation of bone mineral density and bone mineral content in a Chinese population

  • Yan FengAffiliated withProgram for Population Genetics, Harvard School of Public Health
  • , Yi-Hsiang HsuAffiliated withProgram for Population Genetics, Harvard School of Public Health
  • , Henry TerwedowAffiliated withProgram for Population Genetics, Harvard School of Public Health
  • , Changzhong ChenAffiliated withProgram for Population Genetics, Harvard School of Public Health
  • , Xin XuAffiliated withProgram for Population Genetics, Harvard School of Public HealthProgram for Population Genetics, Harvard School of Public HealthAnhui Medical University Institute of Medicine
  • , Tianhua NiuAffiliated withProgram for Population Genetics, Harvard School of Public Health
  • , Tonghua ZangAffiliated withAnhui Medical University Institute of Medicine
  • , Di WuAffiliated withAnhui Medical University Institute of Medicine
  • , Genfu TangAffiliated withAnhui Medical University Institute of Medicine
    • , Zhiping LiAffiliated withAnhui Medical University Institute of Medicine
    • , Xiumei HongAffiliated withAnhui Medical University Institute of Medicine
    • , Binyan WangAffiliated withProgram for Population Genetics, Harvard School of Public Health
    • , Joseph D. BrainAffiliated withProgram for Population Genetics, Harvard School of Public HealthDepartment of Enironmental Health, Harvard School of Public Health
    • , Steven R. CummingsAffiliated withSan Francisco Coordinating Center, UCSF
    • , Clifford RosenAffiliated withMaine Center for Osteoporosis Research and Education, St. Joseph Hospital
    • , Mary L. BouxseinAffiliated withBeth Israel Deaconess Medical Center
    • , Xiping XuAffiliated withProgram for Population Genetics, Harvard School of Public HealthProgram for Population Genetics, Harvard School of Public HealthAnhui Medical University Institute of Medicine Email author 

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Abstract

Familial aggregation of bone mineral density (BMD) and bone mineral content (BMC) has been shown in twin and familial studies, but most sample sizes were small. We here report a large familial aggregation study in a Chinese population. A total of 13,973 siblings aged 25–64 years from 3,882 families were enrolled from Anhui, China. We assessed the whole-body, hip and lumbar spine BMD and BMC by dual-energy X-ray absorptiometry (DXA). Intra-class correlation coefficients of BMD and BMC between siblings varied among different skeletal sites and between different age groups of male sib-pairs and premenopausal and postmenopausal female sib-pairs, with a range of 0.228 to 0.397. The sibling recurrence risk ratio (λs) of osteoporosis was 2.6 in our population. We also evaluated the joint association of the BMD values of the first siblings and the second siblings with the risk of low BMD (defined as less than the 10th percentile of the same group population) of their younger siblings. If both the first and second siblings’ BMDs were in the lowest tertile, the odd ratios (ORs) of low BMD in their subsequent siblings were 8.32 [95% confidence interval (CI) 5.59–12.39)], 8.71 (95% CI 5.74–13.22) and 5.90 (95% CI 3.57–9.76) for total body, total hip and lumbar spine, respectively. This study demonstrates a significant familial aggregation of BMD and BMC in a large sample of rural Chinese adults.

Keywords

Bone mineral content Bone mineral density Chinese Familial aggregation Siblings