Osteoporosis International

, Volume 16, Issue 9, pp 1141–1149

Efficacy of risedronate administration in osteoporotic postmenopausal women affected by inflammatory bowel disease

  • Stefano Palomba
  • Francesco OrioJr.
  • Francesco Manguso
  • Angela Falbo
  • Tiziana Russo
  • Achille Tolino
  • Libuse Tauchmanovà
  • Annamaria Colao
  • Patrizia Doldo
  • Pasquale Mastrantonio
  • Fulvio Zullo
Original Article

DOI: 10.1007/s00198-005-1927-z

Cite this article as:
Palomba, S., Orio, F., Manguso, F. et al. Osteoporos Int (2005) 16: 1141. doi:10.1007/s00198-005-1927-z

Abstract

Patients with inflammatory bowel disease (IBD) have frequently a bone mineral density (BMD) significantly lower than age-matched healthy subjects. The low BMD observed in IBD patients is related also to a higher incidence of bone fractures. In this prospective randomized study we evaluated the effect of 1-year risedronate administration on bone mass and turnover, and on vertebral fractures in osteoporotic postmenopausal women with IBD in remission. Ninety osteoporotic postmenopausal women were randomized to receive oral risedronate 35 mg/week (risedronate group) or placebo tablets (placebo group; one tab/week). The duration of treatment was 12 months. At entry and after treatment, lumbar spine and hip BMD, and serum osteocalcin (OC) and urinary deoxypyridinoline/creatinine ratio (DPD-Cr) levels were evaluated. Vertebral fractures were assessed from thoracic and lumbar lateral and anterior-posterior spinal radiographs taken at baseline, and from lateral spinal radiographs taken at the end of the study. At study entry, no difference between groups was also detected in BMD and in bone turnover markers. At the end of the study, lumbar spine, trochanter and femoral neck BMD was significantly ( p <0.05) higher in comparison with baseline in the risedronate group, whereas a significant ( p <0.05) decrease was observed in the placebo group. For the same visit, a significant ( p <0.05) difference in lumbar spine, trochanter and femoral neck BMD was detected between groups. After 12-month follow-up, serum OC and urinary DPD-Cr levels were significantly ( p <0.05) lower and higher in comparison with basal values in risedronate and placebo group, respectively. At the same time, a significant ( p <0.05) difference in serum OC and urinary DPD-Cr levels was observed between groups. Throughout the study, the incidence of vertebral fractures was significantly ( p <0.05) lower in the risedronate group than in the placebo group (12.5% vs 34.1%). The relative risk (RR) to develop a new vertebral fracture after 1 year of risedronate administration was of 0.36 (95% confidence interval, 0.14–0.85). In conclusion, risedronate administration is an effective anti-osteoporotic treatment in osteoporotic postmenopausal women with IBD in remission.

Keywords

BisphosphonatesClinical trialsMenopauseOsteoporosisRisedronateTreatments

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2005

Authors and Affiliations

  • Stefano Palomba
    • 1
    • 7
  • Francesco OrioJr.
    • 2
  • Francesco Manguso
    • 3
  • Angela Falbo
    • 1
  • Tiziana Russo
    • 1
  • Achille Tolino
    • 4
  • Libuse Tauchmanovà
    • 2
  • Annamaria Colao
    • 2
  • Patrizia Doldo
    • 5
  • Pasquale Mastrantonio
    • 6
  • Fulvio Zullo
    • 1
  1. 1.Department of Obstetrics and GynecologyUniversity “Magna Graecia” of CatanzaroCatanzaroItaly
  2. 2.Department of Molecular and Clinical Endocrinology and OncologyUniversity “Federico II” of NaplesNaplesItaly
  3. 3.Department of GastroenterologyUniversity “Federico II” of NaplesNaplesItaly
  4. 4.Department of Obstetrics and GynecologyUniversity “Federico II” of NaplesNaplesItaly
  5. 5.Department of GastroenterologyUniversity “Magna Graecia” of CatanzaroCatanzaroItaly
  6. 6.Department of Obstetrics and GynecologyUniversity of MessinaMessinaItaly
  7. 7.NaplesItaly