Osteoporosis International

, Volume 17, Issue 1, pp 85–90

Rationale, objectives and design of the Direct Analysis of Nonvertebral Fracture in the Community Experience (DANCE) Study

  • Paul D. Miller
  • Stuart L. Silverman
  • Deborah T. Gold
  • Kathleen A. Taylor
  • Peiqi Chen
  • Rachel B. Wagman
Original Article

DOI: 10.1007/s00198-005-1915-3

Cite this article as:
Miller, P.D., Silverman, S.L., Gold, D.T. et al. Osteoporos Int (2006) 17: 85. doi:10.1007/s00198-005-1915-3

Abstract

The experience in randomized placebo-controlled clinical trials may differ from that in community practice. The pivotal teriparatide [rhPTH(1–34)] studies were initiated when few therapeutic options for osteoporosis were available. The Direct Analysis of Non-Vertebral Fractures in Community Experience (DANCE) study is a prospective observational trial designed to examine the occurrence of nonvertebral fragility fractures in a large, diverse patient population treated with teriparatide. The occurrence of clinical vertebral fractures and back pain will also be examined, as will bone mineral density, bone mineral content, bone area, safety and tolerability. Subjects will be followed through a course of teriparatide therapy for up to 24 months and for an additional 24 months after cessation of treatment. Therefore, subjects may participate in this study for up to 48 months. DANCE will provide data on the effectiveness and tolerability of teriparatide therapy in clinical practice that will complement the results of published controlled clinical trials.

Keywords

Anabolic drugsDANCENonvertebral fractureOsteoporosisTeriparatide

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2005

Authors and Affiliations

  • Paul D. Miller
    • 1
    • 5
  • Stuart L. Silverman
    • 2
  • Deborah T. Gold
    • 3
  • Kathleen A. Taylor
    • 4
  • Peiqi Chen
    • 4
  • Rachel B. Wagman
    • 4
  1. 1.Department of MedicineUniversity of Colorado Health Sciences Center and Colorado Center for Bone ResearchDenverUSA
  2. 2.Cedars-Sinai Medical Center, GLA VA Health SystemOMC Clinical Research Center and the Department of MedicineLos AngelesUSA
  3. 3.Departments of Psychiatry and Behavioral Sciences, Sociology and Psychology, Social and Health SciencesDuke Aging Center, Duke University Medical CenterDurhamUSA
  4. 4.Eli Lilly and CompanyLilly Corporate CenterIndianapolisUSA
  5. 5.University of Colorado Health Sciences CenterColorado Center for Bone ResearchLakewoodUSA