Osteoporosis International

, 17:46

Self-reported diseases and the risk of non-vertebral fractures: the Tromsø study

  • Luai A. Ahmed
  • Henrik Schirmer
  • Gro K. Berntsen
  • Vinjar Fønnebø
  • Ragnar M. Joakimsen
Original Article

DOI: 10.1007/s00198-005-1892-6

Cite this article as:
Ahmed, L.A., Schirmer, H., Berntsen, G.K. et al. Osteoporos Int (2006) 17: 46. doi:10.1007/s00198-005-1892-6

Abstract

We wanted to estimate the independent fracture risk associated with chronic diseases for men and women separately, adjusting for other known risk factors. This is a population-based study of all those who attended the fourth survey (1994–1995) in the Tromsø Study ( n =27,159) who were followed until 31 December 2000 with respect to non-vertebral fractures. At baseline the age range was 25–98 years. Chronic disease cases were defined by self-report in questionnaires. All non-vertebral fractures were registered by computerized search in radiographic archives in the sole provider of radiographic service in the area. A total of 446 and 803 non-vertebral fractures were registered among men and women, respectively. Self-reported diabetes mellitus, stroke, asthma, hypo- and hyperthyroidism and psychiatric disorders were associated with increased fracture risk. Multivariate analyses showed an independent risk of fractures associated with self-reported diabetes mellitus, hypothyroidism and psychiatric disorders among men. Among women the independent risk was associated with self-reported asthma, hypo- and hyperthyroidism and psychiatric disorders. Self-reported heart disease had a protective effect on wrist fracture, especially in women. Increased burden of chronic diseases increase the risk of all non-vertebral ( P <0.0001), wrist ( P =0.005), proximal humerus ( P =0.0004) and hip fracture ( P =0.0002) in men, and for the proximal humerus ( P =0.003) and hip fracture ( P =0.04) in women. There was an independent fracture risk associated with self-reported diabetes mellitus, asthma, hypo- and hyperthyroidism and psychiatric disorders in men and women. Increasing burden of disease increased fracture risk in both men and women.

Keywords

Chronic disease Independent fracture risk Non-vertebral fractures Risk of fracture 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2005

Authors and Affiliations

  • Luai A. Ahmed
    • 1
  • Henrik Schirmer
    • 1
    • 2
  • Gro K. Berntsen
    • 1
  • Vinjar Fønnebø
    • 1
  • Ragnar M. Joakimsen
    • 3
  1. 1.Institute of Community MedicineUniversity of TromsøTromsøNorway
  2. 2.Department of CardiologyUniversity Hospital of TromsøTromsøNorway
  3. 3.Department of Internal MedicineUniversity Hospital of TromsøTromsøNorway