, Volume 17, Issue 1, pp 46-53

Self-reported diseases and the risk of non-vertebral fractures: the Tromsø study

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Abstract

We wanted to estimate the independent fracture risk associated with chronic diseases for men and women separately, adjusting for other known risk factors. This is a population-based study of all those who attended the fourth survey (1994–1995) in the Tromsø Study ( n =27,159) who were followed until 31 December 2000 with respect to non-vertebral fractures. At baseline the age range was 25–98 years. Chronic disease cases were defined by self-report in questionnaires. All non-vertebral fractures were registered by computerized search in radiographic archives in the sole provider of radiographic service in the area. A total of 446 and 803 non-vertebral fractures were registered among men and women, respectively. Self-reported diabetes mellitus, stroke, asthma, hypo- and hyperthyroidism and psychiatric disorders were associated with increased fracture risk. Multivariate analyses showed an independent risk of fractures associated with self-reported diabetes mellitus, hypothyroidism and psychiatric disorders among men. Among women the independent risk was associated with self-reported asthma, hypo- and hyperthyroidism and psychiatric disorders. Self-reported heart disease had a protective effect on wrist fracture, especially in women. Increased burden of chronic diseases increase the risk of all non-vertebral ( P <0.0001), wrist ( P =0.005), proximal humerus ( P =0.0004) and hip fracture ( P =0.0002) in men, and for the proximal humerus ( P =0.003) and hip fracture ( P =0.04) in women. There was an independent fracture risk associated with self-reported diabetes mellitus, asthma, hypo- and hyperthyroidism and psychiatric disorders in men and women. Increasing burden of disease increased fracture risk in both men and women.

An erratum to this article can be found online at http://dx.doi.org/10.1007/s00198-009-0846-9.