Osteoporosis International

, Volume 17, Issue 4, pp 587–592

Polymorphisms in the bone morphogenetic protein 2 (BMP2) gene do not affect bone mineral density in white men or women

Authors

  • Shoji Ichikawa
    • Department of MedicineIndiana University School of Medicine
  • Michelle L. Johnson
    • Department of MedicineIndiana University School of Medicine
  • Daniel L. Koller
    • Department of Medical and Molecular GeneticsIndiana University School of Medicine
  • Dongbing Lai
    • Department of Medical and Molecular GeneticsIndiana University School of Medicine
  • Xiaoling Xuei
    • Department of Biochemistry and Molecular BiologyIndiana University School of Medicine
  • Howard J. Edenberg
    • Department of Medical and Molecular GeneticsIndiana University School of Medicine
    • Department of Biochemistry and Molecular BiologyIndiana University School of Medicine
  • Siu L. Hui
    • Department of MedicineIndiana University School of Medicine
  • Tatiana M. Foroud
    • Department of Medical and Molecular GeneticsIndiana University School of Medicine
  • Munro Peacock
    • Department of MedicineIndiana University School of Medicine
    • Department of MedicineIndiana University School of Medicine
    • Department of Medical and Molecular GeneticsIndiana University School of Medicine
Original article

DOI: 10.1007/s00198-005-0018-5

Cite this article as:
Ichikawa, S., Johnson, M.L., Koller, D.L. et al. Osteoporos Int (2006) 17: 587. doi:10.1007/s00198-005-0018-5

Abstract

Introduction

Peak bone mineral density (BMD) achieved during adulthood is a major determinant of osteoporotic fracture in later life. Although environmental factors affect peak BMD, it is a highly heritable trait. Recently, bone morphogenetic protein 2 (BMP2) was reported as a susceptibility gene for osteoporotic fractures and low BMD in Icelandic and Danish populations.

Methods

To determine whether polymorphisms in the BMP2 gene contribute to BMD variation in our population of healthy American whites, we tested seven single nucleotide polymorphisms (SNPs), four of which were associated with osteoporotic phenotypes in the previous study. BMD at the femoral neck and lumbar spine (L2–L4) were measured by dual energy X-ray absorptiometry (DXA) in 411 men (age 18–61) and 1,291 pre-menopausal women (age 20–50). SNP genotypes/haplotypes were tested for population-based association with BMD using analysis of variance.

Results

None of the polymorphisms tested reached statistical significance (all p values >0.05) for BMD at the femoral neck or lumbar spine in either gender. Two of the SNP haplotypes spanning the entire BMP2 gene were marginally associated with BMD in men (p values=0.019−0.043). However, these haplotypes would account for only a small, if any, portion of BMD variation and would not be significant after adjustment for multiple comparisons.

Conclusions

These results demonstrate that genetic variations in BMP2 do not substantially contribute to BMD variation in our population of healthy American whites.

Keywords

Bone mineral densityBone morphogenetic protein 2Genetic associationOsteoporosisSingle nucleotide polymorphism

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2006