Osteoporosis International

, Volume 15, Issue 10, pp 785–791

Are inhaled corticosteroids associated with an increased risk of fracture in children?

  • Tjeerd-Pieter van Staa
  • Nick Bishop
  • Hubert G. M. Leufkens
  • Cyrus Cooper
Original Article

DOI: 10.1007/s00198-004-1606-5

Cite this article as:
van Staa, TP., Bishop, N., Leufkens, H.G.M. et al. Osteoporos Int (2004) 15: 785. doi:10.1007/s00198-004-1606-5

Abstract

Inhaled corticosteroids are widely used in the long-term management of asthma in children. Data on the relationship between inhaled corticosteroid therapy and osteoporotic fracture are inconsistent. We address this issue in a large population-based cohort of children aged 4–17 years in the UK (the General Practice Research Database). The incidence rates of fracture among children aged 4–17 years taking inhaled corticosteroids (n=97,387), taking bronchodilators only (n=70 984) and a reference group (n=345,758) were estimated. Each child with a non-vertebral fracture (n=23,984) was subsequently matched by age, sex, practice, and calendar time to one child without a fracture. Fracture incidence was increased in children using inhaled corticosteroids, as well as in those receiving bronchodilators alone. With an average daily beclomethasone dose of 200 μg or less, the crude fracture risk relative to nonusers was 1.10 [95% confidence interval (CI), 0.96–1.26]; with dosage of 201–400 μg, it was 1.23 (95% CI, 1.08–1.39); and with dosages over 400 μg, it was 1.36 (95% CI, 1.11–1.67). This excess risk disappeared after adjustment for indicators of asthma severity. The increased risk of fracture associated with use of inhaled corticosteroids is likely to be the result of the underlying illness, rather than being directly attributable to inhaled corticosteroid therapy.

Keywords

Asthma Children Epidemiology Osteoporosis 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2004

Authors and Affiliations

  • Tjeerd-Pieter van Staa
    • 1
    • 2
    • 3
  • Nick Bishop
    • 4
  • Hubert G. M. Leufkens
    • 2
  • Cyrus Cooper
    • 1
  1. 1.MRC Epidemiology Resource CentreUniversity of SouthamptonSouthamptonUK
  2. 2.Department of Pharmacoepidemiology and PharmacotherapyUtrecht Institute for Pharmaceutical SciencesUtrechtThe Netherlands
  3. 3.Procter & Gamble PharmaceuticalsEghamUK
  4. 4.Academic Child HealthSheffield UniversitySheffieldUK

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