Osteoporosis International

, Volume 14, Issue 11, pp 923–928

Associations of polymorphisms in the vitamin D receptor gene (BsmI and FokI) with bone mineral density in postmenopausal women in Malta

  • C. Vidal
  • C. Grima
  • M. Brincat
  • N. Megally
  • A. Xuereb-Anastasi
Original Article

DOI: 10.1007/s00198-003-1457-5

Cite this article as:
Vidal, C., Grima, C., Brincat, M. et al. Osteoporos Int (2003) 14: 923. doi:10.1007/s00198-003-1457-5

Abstract

Previous studies have suggested that variations in the vitamin D receptor (VDR) gene are related to bone mineral density (BMD). In this study, the T→C transition in the start codon and the G→A polymorphism at the 3′ end of the VDR gene, identified by endonucleases FokI and BsmI, respectively, were analysed and correlated with BMD in postmenopausal Maltese women (n=104). Genotype frequencies observed for the VDR start codon polymorphism (SCP) were CC: 60.4%; CT: 30.7% and TT: 8.9%, while those observed for the 3′ in this study were GG: 16.4%; GA: 51.9%; AA: 31.7%. In postmenopausal women, both lumbar and femoral BMD were observed to be highest in CC homozygotes for the FokI genotype and in GG homozygotes for the BsmI genotype, although in both groups the difference between the genotypes was not statistically significant, even after adjusting BMD for age, BMI and years since menopause. No evidence of linkage disequilibrium between the two alleles was observed.

Keywords

Bone mineral density Maltese Osteoporosis Postmenopausal women VDR gene polymorphisms 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2003

Authors and Affiliations

  • C. Vidal
    • 1
    • 3
  • C. Grima
    • 1
  • M. Brincat
    • 2
  • N. Megally
    • 2
  • A. Xuereb-Anastasi
    • 1
    • 3
  1. 1.Department of PathologyUniversity of Malta Medical SchoolMalta
  2. 2.Department of Obstetrics and GynaecologySt Luke’s HospitalMalta
  3. 3.Institute of Health CareUniversity of MaltaMalta

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