Osteoporosis International

, Volume 14, Issue 8, pp 617–630

Osteoporosis after solid organ and bone marrow transplantation


DOI: 10.1007/s00198-003-1426-z

Cite this article as:
Cohen, A. & Shane, E. Osteoporos Int (2003) 14: 617. doi:10.1007/s00198-003-1426-z


Organ transplantation has become increasingly common as a therapy for end-stage renal, liver, cardiac and pulmonary disease. The population of patients who have survived organ transplantation has grown dramatically over the last 2 decades. Although organ transplant recipients now benefit from greatly improved survival, long-term complications of organ transplantation, such as osteoporosis, adversely affect quality of life and must be addressed. In the early post-transplantation period, the effects of high dose glucocorticoids, combined with other immunosuppressive drugs such as cycosporine A and tacrolimus, cause rapid bone loss particularly at the spine and proximal femur. In this setting, fracture incidence rates as high as 25–65% have been reported. Treatment and prevention strategies must target this early post-transplant period, as well as the patient awaiting transplantation and the long-term transplant recipient. This review will discuss the clinical features of transplantation osteoporosis, the pathophysiology of post-transplantation bone loss and prevention and therapy of this unique bone disease.



Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2003

Authors and Affiliations

  1. 1.College of Physicians & Surgeons of Columbia UniversityNew YorkUSA