International Urogynecology Journal

, Volume 12, Supplement 2, pp S19–S23

Influence of Different Sling Materials on Connective Tissue Metabolism in Stress Urinary Incontinent Women

  • C. Falconer
  • M. Söderberg
  • B. Blomgren
  • U. Ulmsten
Symposium

DOI: 10.1007/s001920170007

Cite this article as:
Falconer, C., Söderberg, M., Blomgren, B. et al. Int Urogynecol J (2001) 12: S19. doi:10.1007/s001920170007

Abstract:

The aim of this study was to investigate the influence on the paraurethral connective tissue of different sling materials used in incontinence surgery. Biopsies from the paraurethral connective tissue were obtained intraoperatively from 16 women with stress urinary incontinence; all were operated on with the TVT procedure, 6 with Mersilene as the sling material and 10 with Prolene. Biopsies from 4 continent women with uterine bleeding irregularities, matched for age and parity, served as controls. New biopsies were obtained from all women after 2 years. The biopsies were examined histologically and analyzed for collagen concentration and solubility. An obvious inflammatory reaction with a significant increase in collagen extractability by pepsin was identified in patients where Mersilene was used as the sling material. A minimal inflammatory reaction without a significant change in collagen solubility was found in the Prolene group. In the control group no inflammatory reaction was seen. Mersilene gave rise to a significant foreign-body reaction in the paraurethral connective tissue after surgery. Such a reaction was not found with Prolene.

Key words:Connective tissue metabolism – Stress urinary incontinence – TVT surgical procedure

Copyright information

© Springer-Verlag London Limited 2001

Authors and Affiliations

  • C. Falconer
    • 1
  • M. Söderberg
    • 1
  • B. Blomgren
    • 2
  • U. Ulmsten
    • 3
  1. 1.Karolinska Institute, Danderyd Hospital, StockholmSE
  2. 2.AstraZeneca R&D, Söderta¨ljeSE
  3. 3.Uppsala University Hospital, Uppsala, SwedenSE