International Urogynecology Journal

, Volume 24, Issue 10, pp 1679–1686

Total transvaginal mesh (TVM) technique for treatment of pelvic organ prolapse: a 5-year prospective follow-up study

Authors

    • Department of Obstetrics and GynaecologyEstaing University Hospital
    • Department of Obstetrics-Gynaecology-Human ReproductionEstaing University Hospital
  • P. Hinoul
    • Medical Affairs, Ethicon
  • J. Gauld
    • Clinical Development, Ethicon
  • B. Fatton
    • Department of Obstetrics and GynaecologyEstaing University Hospital
  • C. Rosenthal
    • Department of GynaecologySaint Germain Private Hospital
  • H. Clavé
    • Department of GynaecologySaint George Private Clinic
  • O. Garbin
    • Department of Obstetrics and GynaecologySIHCUS-CMCO University Hospital
  • J. Berrocal
    • Department of GynaecologyL’Europe Private Clinic
  • R. Villet
    • Department of GynaecologyDiaconesses Hospital
  • D. Salet-Lizée
    • Department of GynaecologyDiaconesses Hospital
  • P. Debodinance
    • Department of Obstetrics and GynaecologyGeneral Hospital Dunkerque
  • M. Cosson
    • Department of Obstetrics and GynaecologyJeanne de Flandre University Hospital
Original Article

DOI: 10.1007/s00192-013-2080-4

Cite this article as:
Jacquetin, B., Hinoul, P., Gauld, J. et al. Int Urogynecol J (2013) 24: 1679. doi:10.1007/s00192-013-2080-4

Abstract

Introduction and hypothesis

To evaluate clinical effectiveness and complication rates at 5 years following the total Trans Vaginal Mesh (TVM) technique to treat pelvic organ prolapse.

Methods

Prospective, observational, multi-centre study in patients with prolapse of stage II or higher.

Results

Of the 90 women enrolled in the study, 82 (91 %) were available for the 5-year follow-up period. At the 5-year endpoint, success, defined as no surgical prolapse reintervention and leading edge <−1 (International Continence Society [ICS] criteria) or above the level of the hymen, was 79 % and 87 % respectively. A composite criterion of success defined as: leading edge above the hymen (<0) and no bulge symptoms and no reintervention for prolapse was met by 90 %, 88 % and 84 % at the 1-, 3-, and 5-year endpoints respectively. Quality of life improvement was sustained over the 5 years. Over the 5-year follow-up period, a total of only 4 patients (5 %) required re-intervention for prolapse, while a total of 14 patients (16 %) experienced mesh exposure for which 8 resections needed to be performed. Seven exposures were still ongoing at the 5-year endpoint, all asymptomatic. Only 33 out of 61 (54 %) sexually active patients at baseline remained so at 5 years. De novo dyspareunia was reported by 10 %, but no new cases at the 5-year endpoint. One patient reported de novo unprovoked mild pelvic pain at 5 years, 5 reported pains during pelvic examination only.

Conclusions

Five-year results indicated that TVM provided a stable anatomical repair. Improvements in QOL and associated improvements in prolapse-specific symptoms were sustained. Minimal new morbidity emerged between the 1- and 5-year follow-up.

Keywords

MeshPelvic organ prolapsePolypropyleneProliftTransvaginal meshVaginal surgery

Abbreviations

BMI

Body mass index

ICS

International Continence Society

LOCF

Last observation carried forward

POP

Pelvic organ prolapse

POP-Q

Pelvic organ prolapse quantification

PSI

Prolapse-specific inventory

QOL

Quality of life

SD

Standard deviation

SUI

Stress urinary incontinence

TVM

Transvaginal mesh

Copyright information

© The International Urogynecological Association 2013