International Urogynecology Journal

, Volume 22, Issue 9, pp 1075–1083

Development of cellular therapy for the treatment of stress urinary incontinence

  • Hung-Jen Wang
  • Yao-Chi Chuang
  • Michael B. Chancellor
Review Article

DOI: 10.1007/s00192-011-1432-1

Cite this article as:
Wang, H., Chuang, Y. & Chancellor, M.B. Int Urogynecol J (2011) 22: 1075. doi:10.1007/s00192-011-1432-1

Abstract

Stress urinary incontinence (SUI) is highly prevalent and associated with a reduced quality of life. An intact rhabdosphincter at the mid-urethra is mandatory to maintain urinary continence. Adult stem cell injection therapy for the regenerative repair of an impaired sphincter is currently at the forefront of incontinence research. The implanted cells will fuse with muscle and release trophic factors promoting nerve and muscle integration. Hereby, we review the use of mesenchymal stem cell therapy for SUI and the experience with the development of muscle-derived stem cells.

Keywords

Mesenchymal stem cellsMuscle-derived stem cellsStem cell therapyStress urinary incontinence

Copyright information

© The International Urogynecological Association 2011

Authors and Affiliations

  • Hung-Jen Wang
    • 1
  • Yao-Chi Chuang
    • 1
  • Michael B. Chancellor
    • 2
  1. 1.Department of Urology, Chang Gung Memorial Hospital Kaohsiung Medical CenterChang Gung University College of MedicineKaohsiungTaiwan
  2. 2.Department of UrologyOakland University William Beaumont School of MedicineRoyal OakUSA