Extraordinary muscular structure leads to urethral injury after vaginal delivery in animal study
- Hung-Yen ChinAffiliated withMedical School, Chang Gung UniversityDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital Email author
- , Eileen ChangchienAffiliated withR & D, Standard Chemical and Pharmaceutical. Co., Ltd
- , Chi-Hsin ChiangAffiliated withDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital
- , Hsiu-Ping YangAffiliated withDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital
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Introduction and hypothesis
The aim of this study is to explore causality of birth trauma after vaginal delivery and anatomical findings.
A total of 28 virgin mice were studied. Treatment groups received vaginal distention. Specimens were collected and subjected to the following fluorescence stains: progenitor cell (c-kit), smooth muscle (SMA), fibroblast (vimentin), and skeleton muscle (Masson’s trichrome). Confocal microscopy was used to screen all of the urogenital tissue to localize the stained cells.
Fibroblasts were spread all over perivaginal and urethral surroundings. Progenitor cells appeared at urethral–vagina intersection and urethral circle. They were noticeable only within smooth muscle layer. Two extraordinary skeleton muscle bands appeared on the urethra bilaterally.
Our study demonstrates existence of muscle bands at the bilateral urethra. They can limit the mobility of urethra during vaginal delivery and thereby cause urethra injury. Progenitor cells are located only in the smooth muscle of the urethral circle.
KeywordsBirth trauma Fibrosis Stem cells Urethral injury Urinary incontinence Urogenital structure
- Extraordinary muscular structure leads to urethral injury after vaginal delivery in animal study
International Urogynecology Journal
Volume 21, Issue 10 , pp 1231-1236
- Cover Date
- Print ISSN
- Online ISSN
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- Birth trauma
- Stem cells
- Urethral injury
- Urinary incontinence
- Urogenital structure
- Industry Sectors
- Author Affiliations
- 1. Medical School, Chang Gung University, Tao-Yuan, Taiwan, Republic of China
- 3. Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, No. 222, Mai-Chin Rd., Keelung, 204, Taiwan, Republic of China
- 2. R & D, Standard Chemical and Pharmaceutical. Co., Ltd, Tainan, Taiwan, Republic of China