Evaluating the porcine dermis graft InteXen® in three-compartment transvaginal pelvic organ prolapse repair
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- Ramanah, R., Mairot, J., Clement, M. et al. Int Urogynecol J (2010) 21: 1151. doi:10.1007/s00192-010-1153-x
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Introduction and hypothesis
The aim was to assess the efficacy of three-compartment pelvic organ prolapse (POP) vaginal repair using the InteXen® biocompatible porcine dermal graft as compared to traditional colporrhaphy with sacrospinous ligament suspension.
Preoperative, operative, postoperative and follow-up data were collected retrospectively. Objective recurrence was defined as POP quantification ≥ stage II and subjective recurrence as a symptomatic bulge.
Each group consisted of 63 patients. Surgery time was longer using InteXen® (72 ± 24.5 vs 55 ± 23.5 min, p = 0.0002). Length of hospital stay (4.6 ± 1.6 vs 4.9 ± 2.1 days, p = 0.34) as well as duration of follow-up (37.1 vs 35.7 months, p = 0.45) were equivalent between the two groups. No case of mesh erosion or infection was noted. The objective (17% vs 8%, p = 0.12) and subjective recurrence rates (13% vs 5%, p = 0.12) between the two groups were not statistically different.
InteXen® was well tolerated but had similar efficacy to traditional colporrhaphy and sacrospinous ligament suspension.
KeywordsComparative studyPorcine dermal graftRecurrenceThree-compartment pelvic organ prolapse repairColporrhaphySacrospinous ligament suspension
Pelvic organ prolapse
Group of patients treated with InteXen®
Group of patients treated with traditional colporrhaphy and sacrospinous ligament suspension
Pelvic organ prolapse quantification
Body mass index