International Urogynecology Journal

, Volume 21, Issue 9, pp 1151–1156

Evaluating the porcine dermis graft InteXen® in three-compartment transvaginal pelvic organ prolapse repair

  • Rajeev Ramanah
  • Julian Mairot
  • Marie-Caroline Clement
  • Bernard Parratte
  • Robert Maillet
  • Didier Riethmuller
Original Article

DOI: 10.1007/s00192-010-1153-x

Cite this article as:
Ramanah, R., Mairot, J., Clement, M. et al. Int Urogynecol J (2010) 21: 1151. doi:10.1007/s00192-010-1153-x


Introduction and hypothesis

The aim was to assess the efficacy of three-compartment pelvic organ prolapse (POP) vaginal repair using the InteXen® biocompatible porcine dermal graft as compared to traditional colporrhaphy with sacrospinous ligament suspension.


Preoperative, operative, postoperative and follow-up data were collected retrospectively. Objective recurrence was defined as POP quantification ≥ stage II and subjective recurrence as a symptomatic bulge.


Each group consisted of 63 patients. Surgery time was longer using InteXen® (72 ± 24.5 vs 55 ± 23.5 min, p = 0.0002). Length of hospital stay (4.6 ± 1.6 vs 4.9 ± 2.1 days, p = 0.34) as well as duration of follow-up (37.1 vs 35.7 months, p = 0.45) were equivalent between the two groups. No case of mesh erosion or infection was noted. The objective (17% vs 8%, p = 0.12) and subjective recurrence rates (13% vs 5%, p = 0.12) between the two groups were not statistically different.


InteXen® was well tolerated but had similar efficacy to traditional colporrhaphy and sacrospinous ligament suspension.


Comparative studyPorcine dermal graftRecurrenceThree-compartment pelvic organ prolapse repairColporrhaphySacrospinous ligament suspension



Pelvic organ prolapse


Group of patients treated with InteXen®


Group of patients treated with traditional colporrhaphy and sacrospinous ligament suspension


Pelvic organ prolapse quantification


Transobturator tape


Body mass index

Copyright information

© The International Urogynecological Association 2010

Authors and Affiliations

  • Rajeev Ramanah
    • 1
  • Julian Mairot
    • 1
  • Marie-Caroline Clement
    • 2
  • Bernard Parratte
    • 3
  • Robert Maillet
    • 1
  • Didier Riethmuller
    • 1
  1. 1.Department of Gynecologic SurgeryBesancon University Medical CentreBesanconFrance
  2. 2.Department of Medical StatisticsBesancon University Medical CentreBesanconFrance
  3. 3.Department of Pelvic Floor RehabilitationBesancon University Medical CentreBesanconFrance