International Urogynecology Journal

, Volume 21, Issue 4, pp 489–494

Cyclical estrogen and free radical damage to the rabbit urinary bladder

  • Alexandra Rehfuss
  • Catherine Schuler
  • Christina Maxemous
  • Robert E. Leggett
  • Robert M. Levin
Original Article

DOI: 10.1007/s00192-009-1048-x

Cite this article as:
Rehfuss, A., Schuler, C., Maxemous, C. et al. Int Urogynecol J (2010) 21: 489. doi:10.1007/s00192-009-1048-x

Abstract

Introduction and hypothesis

There are a number of lower urinary tract dysfunctions (LUTD) that occur primarily in women. Our hypothesis is that cyclical estrogen will produce LUTD in part by the generation of free radicals and oxidative damage to cellular and subcellular membranes.

Methods

Twenty female rabbits were divided into five groups: control, ovariectomized (Ovx), Ovx receiving continuous estrogen, Ovx receiving cyclical estrogen ending off estrogen, and Ovx receiving cyclical estrogen ending on estrogen. Statistical analyses used ANOVA followed by the Tukey analysis for individual differences.

Results

High estrogen increased bladder mass, contraction, compliance, and blood flow and decreased oxidative damage. Low estrogen decreased bladder mass, contraction, compliance, and blood flow and increased oxidative damage.

Conclusions

The decreased blood flow associated with increased oxidative damage demonstrates that cyclical damage to cellular membranes occurs. This supports the hypothesis that cycling estrogen may play a role in the etiology of LUTD of women.

Keywords

Bladder Estrogen Free radicals Ischemia Ovariectomy Rabbit 

Copyright information

© The International Urogynecological Association 2009

Authors and Affiliations

  • Alexandra Rehfuss
    • 1
    • 2
  • Catherine Schuler
    • 1
    • 2
  • Christina Maxemous
    • 1
    • 2
  • Robert E. Leggett
    • 1
    • 2
  • Robert M. Levin
    • 1
    • 2
  1. 1.Albany College of Pharmacy and Health SciencesAlbanyUSA
  2. 2.Stratton VA Medical CenterAlbanyUSA

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