Original Article

International Urogynecology Journal

, Volume 14, Issue 5, pp 305-309

First online:

Sacral neuromodulation in patients with interstitial cystitis: a multicenter clinical trial

  • Kristene E. WhitmoreAffiliated withDepartment of Urology, Graduate Hospital
  • , Christopher K. PayneAffiliated withDepartment of Urology, Stanford University
  • , Ananias C. DioknoAffiliated withDepartment of Urology, William Beaumont Hospital
  • , James Chivian LukbanAffiliated withDepartment of Urology, Graduate HospitalColorado Gynecology and Continence Center Email author 

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Female patients with interstitial cystitis (IC) unresponsive to standard oral and intravesical therapy were enrolled at three clinical sites for percutaneous sacral nerve root stimulation (PNS) in a prospective, observational pilot study. Evaluation was in the form of a 3-day voiding diary completed both prior to and following the commencement of sacral nerve root stimulation. Symptoms were also assessed by the O'Leary–Sant Interstitial Cystitis Symptom and Problem Indices (ICSI and ICPI). Baseline and test stimulation values for voiding diary parameters and O'Leary–Sant scores were compared to determine treatment efficacy. A total of 33 patients were enrolled. Statistically significant improvements were seen in frequency, pain, average voided volume and maximum voided volume. Significant improvements were also seen in ICSI and ICPI scores. Subacute PNS appears to be effective in reducing symptom severity and increasing voided volumes in patients with IC previously unresponsive to standard therapy.


Frequency Interstitial cystitis Pelvic pain Sacral neuromodulation Urgency