Intensive Care Medicine

, Volume 27, Issue 9, pp 1481–1486

Acute cor pulmonale in massive pulmonary embolism: incidence, echocardiographic pattern, clinical implications and recovery rate

  • Antoine Vieillard-Baron
  • Bernard Page
  • Roch Augarde
  • Sebastien Prin
  • Salah Qanadli
  • Alain Beauchet
  • Olivier Dubourg
  • François Jardin
Original

DOI: 10.1007/s001340101032

Cite this article as:
Vieillard-Baron, A., Page, B., Augarde, R. et al. Intensive Care Med (2001) 27: 1481. doi:10.1007/s001340101032

Abstract.

Objective: The indications for the use of thrombolytic agents in massive pulmonary embolism (MPE) remain controversial and it has been suggested that transthoracic echocardiographic (TTE) examination, which is able to detect an associated right ventricular dysfunction, may cast light on this question. The goal of this study was to examine the incidence of acute cor pulmonale (ACP) in MPE, diagnosed on the basis of TTE criteria, its clinical implications and its resolution rate. Design: Ten-year retrospective clinical study. Setting: A medical and a coronary intensive care unit, university hospital. Patients: One hundred sixty-one patients with proven MPE. Interventions: Acute cor pulmonale was defined as right ventricular end-diastolic area / left ventricular end-diastolic area (RVEDA/LVEDA) ratio in the long axis greater than 0.6 associated with septal dyskinesia in the short axis. ACP patients were divided into three groups according to circulatory status: 32 patients without circulatory failure constituted group 1, 32 patients with circulatory failure requiring inotropic support, but free of metabolic acidosis, constituted group 2 and 34 patients in whom circulatory failure was associated with metabolic acidosis (defined by a base deficit >5 mEq/l) constituted group 3. Results: Acute cor pulmonale was present in 61% of patients with MPE and carried a 23% mortality, but this mortality was very different in stable patients (groups 1 and 2, 64 patients, 3% mortality) and in unstable patients (group 3, 34 patients, 59% mortality). A multivariate logistic regression analysis showed that the TTE results were not predictive of the risk of death. Conversely, the same analysis showed that the presence of metabolic acidosis was a powerful predictor of death. Conclusion: Because none of the TTE measurements in ACP could be used to stratify the severity of MPE, TTE was of no help in deciding on medical thrombolysis. However, depending on its severity, metabolic acidosis could justify a large cooperative study to assess the impact of thrombolytic therapy on mortality rate in this specific group.

Massive pulmonary embolism Acute cor pulmonale Echocardiography Metabolic acidosis Thrombolysis Recombinant tissue-type plasminogen activator 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Antoine Vieillard-Baron
    • 1
  • Bernard Page
    • 1
  • Roch Augarde
    • 1
  • Sebastien Prin
    • 1
  • Salah Qanadli
    • 2
  • Alain Beauchet
    • 3
  • Olivier Dubourg
    • 4
  • François Jardin
    • 1
  1. 1.Medical Intensive Care Unit, University Hospital Ambroise Paré, Assistance Publique Hôpitaux de Paris, 9 avenue Charles de Gaulle, 92104, Boulogne Cedex, FranceFrance
  2. 2.Department of Radiology, University Hospital Ambroise Paré, Assistance Publique Hôpitaux de Paris, 9 avenue Charles de Gaulle, 92104, Boulogne Cedex, FranceFrance
  3. 3.Department of Biostatistics, University Hospital Ambroise Paré, Assistance Publique Hôpitaux de Paris, 9 avenue Charles de Gaulle, 92104, Boulogne Cedex, FranceFrance
  4. 4.Department of Cardiology, University Hospital Ambroise Paré, Assistance Publique Hôpitaux de Paris, 9 avenue Charles de Gaulle, 92104, Boulogne Cedex, FranceFrance

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