, Volume 27, Issue 5, pp 803-811
Date: 12 Apr 2001

Pathogenesis and treatment of renal dysfunction in rhabdomyolysis

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Abstract

Rhabdomyolysis is a major cause of acute renal failure, and recent experimental data have provided a better understanding of the pathophysiology of the renal dysfunction. Renal failure is due to renal vasoconstriction, tubular damage caused by oxidant injury, and possibly tubular obstruction. Recent studies have provided greater insight into the rationale behind current therapy and potential treatment strategies. This review thus aims to summarise current understanding of the causes, pathogenesis and treatment of renal failure caused by rhabdomyolysis.

Final revision received: 7 January 2001
Electronic Publication