Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment
- First Online:
- Cite this article as:
- Scalfaro, P., Chesaux, J.J., Buchwalder, P.A. et al. Intensive Care Med (1998) 24: 247. doi:10.1007/s001340050558
- 67 Downloads
Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this long-term treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood.