Intensive Care Medicine

, Volume 24, Issue 3, pp 247–250

Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment

  • P. Scalfaro
  • J. J. Chesaux
  • P. A. Buchwalder
  • J. Biollaz
  • J. L. Micheli
Neonatal And Pediatric Intensive Care

DOI: 10.1007/s001340050558

Cite this article as:
Scalfaro, P., Chesaux, J.J., Buchwalder, P.A. et al. Intensive Care Med (1998) 24: 247. doi:10.1007/s001340050558

Abstract

Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this long-term treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood.

Key words

HIV infectionZidovudineNeonateProphylaxisLactic acidosis

Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  • P. Scalfaro
    • 1
  • J. J. Chesaux
    • 2
  • P. A. Buchwalder
    • 3
  • J. Biollaz
    • 3
  • J. L. Micheli
    • 1
  1. 1.Division of NeonatologyUniversity HospitalLausanneSwitzerland
  2. 2.Department of PaediatricsUniversity HospitalLausanneSwitzerland
  3. 3.Division of Clinical PharmacologyUniversity HospitalLausanneSwitzerland
  4. 4.Telethon Institute for Child Health ResearchPrincess Margaret Hospital for ChildrenWest PerthAustralia