Intensive Care Medicine

, Volume 40, Issue 9, pp 1220–1226

A paper on the pace of recovery from diaphragmatic fatigue and its unexpected dividends

  • Franco Laghi
  • Nausica D’Alfonso
  • Martin J. Tobin
My Paper 20 Years Later

DOI: 10.1007/s00134-014-3340-6

Cite this article as:
Laghi, F., D’Alfonso, N. & Tobin, M.J. Intensive Care Med (2014) 40: 1220. doi:10.1007/s00134-014-3340-6

Abstract

Because the diaphragm is essential for survival, we wondered if it might be less vulnerable to the long-lasting effects of fatigue than limb muscles. Using a recently introduced magnetic probe to activate the phrenic nerves, we followed the evolution of twitch transdiaphragmatic pressure after inducing fatigue in healthy volunteers. Twenty-four hours after its induction, diaphragmatic fatigue had not fully recovered. Findings from this study later served as the foundation for incorporating a once-daily, T-tube-trial arm into a randomized controlled trial of techniques for ventilator weaning in intensive care unit patients and also influenced the design of a controlled trial of the weaning of tracheostomy patients who required prolonged ventilation. The research methodology was later employed to determine whether low-frequency fatigue is responsible for weaning failure. Employing a further modification of the technique—twitch airway pressure—it became evident that respiratory muscle weakness is a greater problem than fatigue in ventilated patients. Twitch airway pressure is now being used to document the prevalence and consequences of ventilator-induced respiratory muscle weakness. Our study—which began with a circumscribed, simple question—has yielded dividends in unforeseen directions, illustrating the fruitfulness of research into basic physiological mechanisms.

Keywords

Respiratory musclesMechanical ventilationDiaphragm weaknessAtrophyVentilator-induced diaphragmatic dysfunctionWeaning

Copyright information

© Springer-Verlag Berlin Heidelberg and ESICM 2014

Authors and Affiliations

  • Franco Laghi
    • 1
    • 2
  • Nausica D’Alfonso
    • 1
    • 2
  • Martin J. Tobin
    • 1
    • 2
  1. 1.Division of Pulmonary and Critical Care MedicineEdward Hines, Jr. VA HospitalHinesUSA
  2. 2.Loyola University of Chicago Stritch School of MedicineMaywoodUSA