Intensive Care Medicine

, Volume 39, Issue 1, pp 123–128

Early change in blood glucose concentration is an indicator of mortality in critically ill children

  • Prabhakar P. Nayak
  • Paul Davies
  • Parth Narendran
  • Simon Laker
  • Fang Gao
  • Stephen C. L. Gough
  • John Stickley
  • Kevin P. Morris
Pediatric Original

DOI: 10.1007/s00134-012-2738-2

Cite this article as:
Nayak, P.P., Davies, P., Narendran, P. et al. Intensive Care Med (2013) 39: 123. doi:10.1007/s00134-012-2738-2

Abstract

Objective

Hyperglycaemia is associated with increased mortality in critically ill patients. A number of studies have highlighted an association between increased variability of blood glucose (BG) concentration and mortality, supporting a survival disadvantage if BG homeostasis is lost. By exploring the longitudinal BG profile of individual children over time, this study investigates the importance of intact homeostasis early after admission to the paediatric intensive care unit (PICU).

Design, setting, and patients

Retrospective single-centre observational study in a large multi-specialty PICU in the UK. Children admitted between August 2003 and February 2006 were included unless they met exclusion criteria. Data were merged from the PICU clinical database and blood gas analyser database by means of a unique PICU identifier. BG was measured frequently on a blood gas analyser (Bayer Rapidlink). Primary outcome was 100-day mortality. BG parameters were investigated for possible associations with mortality.

Measurements and main results

A total of 1,763 patients were included (median age 1.1 years; IQR 0.1–5.8). Although admission BG was not associated with mortality, a survival advantage was found in children who showed a reduction in BG on day 1 relative to the admission BG value (p < 0.001). This remained statistically significant (p = 0.007) after adjusting for severity of illness.

Conclusions

This study supports an association between early BG profile and mortality in children admitted to PICU, with increased survival in those who demonstrate a fall in BG on day 1 relative to PICU admission. These findings are consistent with a survival advantage of intact BG homeostasis.

Keywords

HyperglycaemiaGlycaemic controlInsulinCritical careCritical illness

Copyright information

© Springer-Verlag Berlin Heidelberg and ESICM 2012

Authors and Affiliations

  • Prabhakar P. Nayak
    • 1
  • Paul Davies
    • 5
  • Parth Narendran
    • 2
  • Simon Laker
    • 1
  • Fang Gao
    • 3
  • Stephen C. L. Gough
    • 4
  • John Stickley
    • 1
  • Kevin P. Morris
    • 1
  1. 1.Department of Paediatric Intensive Care MedicineBirmingham Children’s Hospital Foundation NHS TrustBirminghamUK
  2. 2.Department of Diabetes and EndocrinologyUniversity of BirminghamBirminghamUK
  3. 3.Department of Critical CareUniversity of BirminghamBirminghamUK
  4. 4.Oxford Centre for DiabetesEndocrinology and Metabolism and NIHR Oxford Biomedical Research CentreOxfordUK
  5. 5.Statistical Advisory ServiceBirmingham Children’s Hospital Foundation NHS TrustBirminghamUK