, Volume 38, Issue 2, pp 192-209,
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Year in review in Intensive Care Medicine 2011: I. Nephrology, epidemiology, nutrition and therapeutics, neurology, ethical and legal issues, experimentals

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Introduction

A number of articles have been published in the fields of neurology, nutrition, epidemiology, nephrology, and ethics, together with interesting experimental investigations. This year, we wanted to integrate the works published in Intensive Care Medicine with the most relevant papers in these various fields published in other distinguished journals.

Nephrology

Acute kidney injury continued to be hot topic in 2011. Early diagnosis remains an issue of increasing importance, with the aim being to install early preventive measures in critically ill patients. Several very promising biomarkers turned out to have serious limitations in specific disease states, e.g. NGAL in septic shock [1, 2]. Cystatin C is another biomarker that is presumed to allow the early detection of small declines in glomerular filtration rate (GFR), but may also reflect tubular damage if measured in the urine. Royakkers et al. [3] investigated both urine and serum cystatin c in a multicentre prospective obser