Intensive Care Medicine

, Volume 37, Issue 7, pp 1128–1135

Severity of ICU-acquired pneumonia according to infectious microorganisms

  • Pierre Damas
  • Nathalie Layios
  • Laurence Seidel
  • Monique Nys
  • Pierrette Melin
  • Didier Ledoux
Original

DOI: 10.1007/s00134-011-2255-8

Cite this article as:
Damas, P., Layios, N., Seidel, L. et al. Intensive Care Med (2011) 37: 1128. doi:10.1007/s00134-011-2255-8

Abstract

Purpose

To assess the severity of intensive care unit (ICU)-acquired pneumonia (ICUAP) according to the bacteria involved, classified into seven groups: third-generation cephalosporin-resistant non-fermenting Gram-negative bacilli (resistant C3NF); sensitive C3NF; methicillin-resistant Staphylococcus aureus; methicillin-sensitive Staphylococcus aureus; extended-spectrum beta-lactamase-producing Enterobacteriaceae; Enterobacteriaceae not producing extended-spectrum beta-lactamase; Haemophilus influenzae and Streptococcus pneumoniae.

Methods

Over a 4-year period, sequential organ failure assessment (SOFA) score was prospectively measured daily in 453 adult patients with ICUAP. ICUAP severity was evaluated by the severity of sepsis and by the occurrence of new organ dysfunctions or failures (OD/F) during ICUAP.

Results

Septic shock occurred in 21% of all cases of ICUAP. The occurrence of new OD/F during ICUAP was similar regardless of the identified microorganism. These new OD/F represented less than 11% of SOFAmax, defined as the sum of all OD/F occurring at any time during the ICU stay. There was a significant association between SOFApreICUAP, defined as the sum of all the OD/F occurring before ICUAP, and ICUAP severity. In the multivariate analysis, the type of bacteria was not a risk factor (RF) for occurrence of septic shock and mortality. Age and SOFApreICUAP were RF for the sepsis severity. The ICUAP severity was an RF for ICU mortality.

Conclusions

ICUAP was responsible for a minor proportion of OD/F occurring during the ICU stay. Severity of ICUAP was related to clinical status prior to ICUAP, but not to the type of bacteria. ICU mortality depended on the severity of ICUAP.

Keywords

ICUSOFA scoreVentilator-associated pneumoniaNosocomial infection

Copyright information

© Copyright jointly held by Springer and ESICM 2011

Authors and Affiliations

  • Pierre Damas
    • 1
  • Nathalie Layios
    • 1
  • Laurence Seidel
    • 2
  • Monique Nys
    • 1
  • Pierrette Melin
    • 3
  • Didier Ledoux
    • 1
  1. 1.Department of General Intensive CareUniversity Hospital of Liege, University of LiegeLiegeBelgium
  2. 2.Department of BiostatisticsUniversity Hospital of Liege, University of LiegeLiegeBelgium
  3. 3.Department of Clinical MicrobiologyUniversity Hospital of Liege, University of LiegeLiegeBelgium