Intensive Care Medicine

, Volume 37, Issue 6, pp 957–962

Emergence of autoantibodies to HMGB1 is associated with survival in patients with septic shock

  • Stéphanie Barnay-Verdier
  • Lakhdar Fattoum
  • Chloé Borde
  • Srini Kaveri
  • Sébastien Gibot
  • Vincent Maréchal
Original

DOI: 10.1007/s00134-011-2192-6

Cite this article as:
Barnay-Verdier, S., Fattoum, L., Borde, C. et al. Intensive Care Med (2011) 37: 957. doi:10.1007/s00134-011-2192-6
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Abstract

Purpose

To assess the prevalence and predictive value of natural autoantibodies to high-mobility group box 1 (HMGB1) during sepsis.

Methods

Anti-HMGB1 and anti-human serum albumin (HSA) autoantibodies were detected by ELISA in 178 plasma samples longitudinally collected from 40 critically ill patients with septic shock. One hundred thirty-two plasma samples from healthy donors were used as control.

Results

IgGs to HMGB1 were detected in 15/40 patients (37.5%). The prevalence of anti-HMGB1 antibodies was significantly higher in the patients who survived (55%) compared to the patients who did not (20%) (p < 0.0001). The detection of anti-HMGB1 antibodies during the course of the disease was significantly associated with patient survival (p = 0.038). Moreover, there is a progressive and significant emergence of anti-HMGB1 antibodies during the course of the disease, mostly in patients who survived.

Conclusions

This study shows that autoantibodies to HMGB1 are produced during sepsis and are associated with a favorable outcome in patients undergoing septic shock.

Keywords

Septic shockHMGB1AutoantibodiesOutcome

Copyright information

© Copyright jointly held by Springer and ESICM 2011

Authors and Affiliations

  • Stéphanie Barnay-Verdier
    • 1
    • 2
    • 3
    • 5
  • Lakhdar Fattoum
    • 1
    • 2
    • 3
  • Chloé Borde
    • 1
    • 2
    • 3
  • Srini Kaveri
    • 1
    • 2
    • 3
  • Sébastien Gibot
    • 4
  • Vincent Maréchal
    • 1
    • 2
    • 3
  1. 1.Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, UMRS 872ParisFrance
  2. 2.Université Paris Descartes, UMRS 872ParisFrance
  3. 3.INSERM, U872ParisFrance
  4. 4.Hôpital Central, Service de Réanimation MédicaleNancyFrance
  5. 5.NiceFrance