, Volume 36, Issue 6, p 1097
Date: 30 Mar 2010

Hydrocortisone therapy for patients with H1N1 influenza A infection

This is an excerpt from the content

Dear editor: We read with interest Quispe-Laime and colleagues’ work [1] which described the clinical presentation of 13 consecutive patients and their response to combination high-dose oseltamivir and prolonged low-to moderate dose corticosteroid treatment.

A systematic review [2] suggested that prolonged low-dose corticosteroid therapy decreases mortality and recommended treating adult patients with vasopressor-dependent septic shock. Annane and colleagues [3] had shown that a 7-day treatment with the combination of low doses of hydrocortisone and 9-α-fludrocortisone significantly improved survival at day 28 and at Intensive Care Unit and hospital discharge, and reduced the duration of mechanical ventilation in patients with septic shock associated early acute respiratory distress syndrome (ARDS) and a weak cortisol response to corticotropin without inducing serious adverse events. There is insufficient evidence to support steroid administration for sepsis with shock, regardless of a

The author’s reply to this comment is available at: doi:10.1007/s00134-010-1816-6.