Clinical Perspective

Intensive Care Medicine

, Volume 35, Issue 12, pp 2028-2032

Vitamin D deficiency in the intensive care unit: an invisible accomplice to morbidity and mortality?

  • Paul LeeAffiliated withDepartment of Endocrinology, St Vincent’s HospitalDepartment of Endocrinology, Garvan Institute of Medical ResearchUniversity of New South Wales Email author 
  • , Priya NairAffiliated withIntensive Care Unit, St Vincent’s Hospital
  • , John A. EismanAffiliated withDepartment of Endocrinology, St Vincent’s HospitalDepartment of Endocrinology, Garvan Institute of Medical ResearchBone and Mineral Research Programme, Garvan Institute of Medical ResearchUniversity of New South Wales
  • , Jacqueline R. CenterAffiliated withDepartment of Endocrinology, St Vincent’s HospitalDepartment of Endocrinology, Garvan Institute of Medical ResearchBone and Mineral Research Programme, Garvan Institute of Medical ResearchUniversity of New South Wales

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Abstract

The association between vitamin D deficiency and chronic illness is well-known. Vitamin D deficiency has been associated with increased mortality in the general population. Despite this knowledge, vitamin D insufficiency is seldom considered and rarely replaced adequately, if at all, in critically ill patients in intensive care. We present a hypothetic model demonstrating how vitamin D deficiency may be an unrecognized contributor to adverse outcome in intensive care patients.

Keywords

Endocrine disorders Electrolyte disorders Multiple organ failure Nutrition Systemic diseases Cardiovascular issues in the ICU Vitamin D deficiency Hypocalcaemia