Intensive Care Medicine

, Volume 35, Issue 8, pp 1484–1487

Blood acidification enhances carbon dioxide removal of membrane lung: an experimental study

Authors

  • Alberto Zanella
    • Department of Experimental MedicineUniversity of Milano-Bicocca
  • Nicolò Patroniti
    • Department of Experimental MedicineUniversity of Milano-Bicocca
  • Stefano Isgrò
    • Department of Experimental MedicineUniversity of Milano-Bicocca
  • Mariangela Albertini
    • Dipartimento di Patologia animale, Igiene e Sanità pubblica veterinaria, sez. di Biochimica e FisiologiaUniversità degli studi di Milan
  • Marco Costanzi
    • Dipartimento di Patologia animale, Igiene e Sanità pubblica veterinaria, sez. di Biochimica e FisiologiaUniversità degli studi di Milan
  • Federica Pirrone
    • Dipartimento di Patologia animale, Igiene e Sanità pubblica veterinaria, sez. di Biochimica e FisiologiaUniversità degli studi di Milan
  • Vittorio Scaravilli
    • Department of Experimental MedicineUniversity of Milano-Bicocca
  • Beatrice Vergnano
    • Department of Experimental MedicineUniversity of Milano-Bicocca
    • Department of Experimental MedicineUniversity of Milano-Bicocca
    • Department of Experimental Medicine (DIMS)University of Milan-Bicocca
Physiological and Technical Notes

DOI: 10.1007/s00134-009-1513-5

Cite this article as:
Zanella, A., Patroniti, N., Isgrò, S. et al. Intensive Care Med (2009) 35: 1484. doi:10.1007/s00134-009-1513-5

Abstract

Purpose

Extracorporeal CO2 removal is an effective procedure to allow a protective ventilatory strategy in ARDS patients, but it is technically challenging due to the high blood flow required. Increasing the CO2 transfer through the membrane lung (ML) may lower the demand of extracorporeal blood flow and consequently allow for a wider clinical application of this technique. Since only the dissolved CO2 (5% of the total CO2 content) is easily removed by the ML, we tested whether acidifying the blood entering the ML to convert bicarbonate ions towards dissolved CO2 could enhance the CO2 transfer though the ML.

Methods

Six pigs were connected to an extracorporeal circuit comprising a ML. The extracorporeal blood flow was 500 ml/min, while the gas flow was 10 l/min. A 15-min continuous infusion of 0.5 N lactic acid was added to the extracorporeal blood flow before the ML at a rate of 1, 2 and 5 mEq/min. Between steps we waited for a reequilibration time of at least 30 min.

Results

Acid infusion at 0, 1, 2 and 5 mEq/min increased pCO2 (56.19 ± 7.92, 68.24 ± 11.73, 84.28 ± 11.17 and 136.66 ± 18.46 mmHg, respectively) and decreased pH (7.39 ± 0.05, 7.30 ± 0.05, 7.20 ± 0.05 and 6.91 ± 0.05, respectively). ML CO2 removal increased 11, 23 and 70% during acid infusion at 1, 2 and 5 mEq/min, respectively.

Conclusions

Blood acidification at the inlet of a ML with infusion of 1, 2 and 5 mEq/min of lactic acid can increase the CO2 removal capacity of the ML up to 70%.

Keywords

Extracorporeal CO2 removal (ECCO2R) Ventilator-induced lung injury (VILI) Lactic acid Acute respiratory distress syndrome (ARDS) Extracorporeal life support (ECLS)

Copyright information

© Springer-Verlag 2009