Can we use pulse pressure variations to predict fluid responsiveness in patients with ARDS?
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- Lefrant, J. & De Backer, D. Intensive Care Med (2009) 35: 966. doi:10.1007/s00134-009-1479-3
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Respiratory variations in stroke volume have been shown to be associated with preload dependency in mechanically ventilated patients without spontaneous breathing movements. Pulse pressure variations (ΔPP), a surrogate of stroke volume variation (SVV), predict fluid responsiveness better than static indices of cardiac preload [1, 2]. However, SVVs and ΔPP are caused by respiratory-induced changes in preload that may be limited when patients are ventilated at low tidal volume. The reliability of ΔPP could hence be theoretically limited in mechanically ventilated patients with low tidal volume . An experimental study showed that changes in SVV between hemorrhage and fluid loading were limited when tidal volume was 5 ml/kg in contrast with larger changes at 10 and 15 ml/kg . In mechanically ventilated acute respiratory distress syndrome (ARDS) patients, De Backer et al.  reported that the predictive value of ΔPP for fluid responsiveness decreased when a tidal volume lower than 8 ml/kg was applied [area under the ROC (AUC ROC) = 0.71 ± 0.09]. A similar AUC ROC (0.768) was recently reported in 22 ARDS patients ventilated with tidal volume ranging from 5.3 to 8.3 ml/kg .
Unfortunately, ΔPP is thus less reliable in patients with ARDS, who are often ventilated with small tidal volumes as part of protective mechanical ventilation, and these patients may particularly suffer for unjustified fluid administration. In the present issue, Vallée et al.  hypothesized that adjusting ΔPP value for variations in alveolar pressure could be more reliable than ΔPP alone in predicting fluid responsiveness. As alveolar pressure cannot be directly measured, they used changes in driving pressure (ΔP = Pplat − PEEPtot) as a surrogate. In 84 mechanically ventilated ICU patients, the reliability of ΔPP/ΔP in predicting fluid responsiveness was better than ΔPP (ROC AUC = 0.81 vs. 0.71; P < 0.01). In patients in whom a tidal volume ≥8 ml/kg was applied, the prediction of fluid responsiveness was even better (ΔPP/ΔP ROC AUC = 0.88 vs. 0.75; P < 0.01). However, in patients with tidal volume <8 ml/kg, ΔPP/ΔP failed to predict fluid responsiveness (ROC AUC = 0.62 vs. 0.72). The authors concluded that ΔPP/ΔP better predicted the response to fluids than ΔPP for patients ventilated with a tidal volume ≥8 ml/kg but failed to predict fluid responsiveness in patients ventilated at lower tidal volumes.
Driving pressure calculated from airway and esophageal pressures (recalculated from mean values provided in study by Talmor et al. )
Esophageal pressure-guided group (n = 30)
Conventional treatment group (n = 31)
Plateau pressure (cmH2O)
End-expiratory pressure (cmH2O)
Driving pressure from esophageal pressure airway pressures (ΔP) (cmH2O)
Esophageal end-inspiratory pressure (cmH2O)
Esophageal end-expiratory pressure (cmH2O)
Driving pressure from esophageal pressure (cmH2O)
Another important finding from this study is that correcting ΔPP for tidal volume did not result in better performance than ΔPP/ΔP, further illustrating that the relationship between tidal volume and changes in pleural and pericardial pressure is complex and nonlinear.
What can we do in practice to predict fluid responsiveness in patients with ARDS ventilated with tidal volumes lower than 8 ml/kg? One consideration would be to use a lower cut-off for ΔPP. De Backer et al.  noticed that an 8% value satisfactorily identified responders and nonresponders to fluids, but we have also to consider that the lower the value the higher the chances that it may be influenced by small errors in measurements. Alternatively, one may consider using the traditional 12% cut-off value, which may be expected to have a low sensitivity but a satisfactory specificity . Finally, one may consider performing a passive leg-raising test [11, 12].
In conclusion, the study by Vallée et al.  confirms that ΔPP remains a clinically helpful tool to predict fluid responsiveness in patients ventilated with tidal volumes of at least 8 ml/kg but that this index has a limited value in patients ventilated at lower tidal volumes. Correction of ΔPP by ΔP improved the performance of the test in patients with relatively healthy lungs but not in patients with ARDS, as the transmission of airway pressure to pleural and pericardial pressure is affected in ARDS.