, Volume 35, Issue 6, p 1148
Date: 17 Feb 2009

Reply to Mion

This is an excerpt from the content

Sir: We thank Dr Mion and his colleagues for their interest in our study [1], and we appreciate that this important topic is such a matter of discussion and concern. Addressing the content of Dr Mion’s letter, however, is made difficult by an unclear meaning of the word “evidence”.

First, Mion et al. argue that our study “solely proves a link between hyperoncotic albumin and probability of renal replacement therapy”. This is strange since our results indicate that “after adjustment on potential confounding factors and on propensity score for the use of hyperoncotic colloids, the use of artificial hyperoncotic colloids [OR: 2.48 (1.24–4.97)] and hyperoncotic albumin [OR: 5.99 (2.75–13.08)] was significantly associated with occurrence of renal event.” This is not an opinion but a result. We therefore concluded, carefully selecting our wording that “this suggests that harmful effects on renal function and outcome of hyperoncotic colloids may exist.” We believe this conclusion is cautious a ...

This reply refers to the comment available at: doi:10.1007/s00134-009-1441-4.