, Volume 35, Issue 7, p 1318
Date: 24 Feb 2009

Blood and tissue glucose level in critically ill patients: a comparison of different methods of measuring interstitial glucose levels

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Sir: Tight glycemic control in critically ill patients may significantly decrease their mortality and morbidity. Mini-invasive techniques for continuous glucose monitoring [the Guardian Real Time (RT) continuous glucose monitoring system and the microdialysis technique] are promising methods for glucose management but clinical trials evaluating the correlation with plasma glucose levels in critically ill patients are missing.

To investigate whether the glucose values obtained by the Guardian RT system and microdialysis could be used instead of blood glucose sampling in mechanically ventilated, critically ill patients we performed a prospective study in which we enrolled 15 patients aged 18 and over, admitted to a multidisciplinary ICU and the preliminary results we presented at the 28th International Symposium on Intensive Care and Emergency Medicine and Euroanasthesia 2008 Congress [1, 2].

A microdialysis catheter (CMA 60, 0.5 × 30 mm membrane, 20 kDa cut-off, CMA Microdialysis, Solna, ...