Intensive Care Medicine

, 35:1152

The impact of obesity on outcomes after critical illness: a meta-analysis

  • Charles W. HogueJr
  • Joshua D. Stearns
  • Elizabeth Colantuoni
  • Karen A. Robinson
  • Tracey Stierer
  • Nanhi Mitter
  • Peter J. Pronovost
  • Dale M. Needham
Review

DOI: 10.1007/s00134-009-1424-5

Cite this article as:
Hogue, C.W., Stearns, J.D., Colantuoni, E. et al. Intensive Care Med (2009) 35: 1152. doi:10.1007/s00134-009-1424-5

Abstract

Purpose

To assess whether obesity is associated with mortality or other adverse intensive care unit (ICU) and post-ICU outcomes.

Methods

A meta-analysis of studies from PubMed and EMBASE databases.

Results

Twenty-two studies (n = 88,051 patients) were included. Pooled analysis demonstrated no difference in ICU mortality, but lower hospital mortality for obese and morbidly obese subjects (RR 0.76; 95% CI 0.59, 0.92; RR 0.83; 95% CI 0.66, 1.04, respectively) versus normal weight subjects. There was no association between obesity and duration of mechanical ventilation or ICU stay. Morbidly obese versus normal weight patients had longer hospitalizations. No study reported physical function, mental health, or quality of life outcomes after discharge.

Conclusions

Obesity is not associated with increased risk for ICU mortality, but may be associated with lower hospital mortality. There is a critical lack of research on how obesity may affect complications of critical illness and patient long-term outcomes.

Keywords

Intensive careCritical illnessMortalityBody weightMeta-analysis

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Charles W. HogueJr
    • 1
    • 2
  • Joshua D. Stearns
    • 1
  • Elizabeth Colantuoni
    • 1
  • Karen A. Robinson
    • 5
  • Tracey Stierer
    • 1
  • Nanhi Mitter
    • 1
  • Peter J. Pronovost
    • 1
  • Dale M. Needham
    • 3
    • 4
  1. 1.Department of Anesthesiology and Critical Care MedicineThe Johns Hopkins Medical InstitutionsBaltimoreUSA
  2. 2.Department of Anesthesiology and Critical Care MedicineThe Johns Hopkins HospitalBaltimoreUSA
  3. 3.Division of Pulmonary and Critical Care Medicine, Department of MedicineThe Johns Hopkins Medical InstitutionsBaltimoreUSA
  4. 4.Department of Physical Medicine and RehabilitationThe Johns Hopkins Medical InstitutionsBaltimoreUSA
  5. 5.Department of MedicineThe Johns Hopkins Medical InstitutionsBaltimoreUSA