Intensive Care Medicine

, 35:1240

Short-term evaluation of sedation with sevoflurane administered by the anesthetic conserving device in critically ill patients

  • Maurizio Migliari
  • Giacomo Bellani
  • Roberto Rona
  • Stefano Isgrò
  • Beatrice Vergnano
  • Tommaso Mauri
  • Nicolò Patroniti
  • Antonio Pesenti
  • Giuseppe Foti
Original

DOI: 10.1007/s00134-009-1414-7

Cite this article as:
Migliari, M., Bellani, G., Rona, R. et al. Intensive Care Med (2009) 35: 1240. doi:10.1007/s00134-009-1414-7

Abstract

Purpose

Assessing feasibility and physiological effects of sedation with sevoflurane, administered with the anesthetic conserving device (AnaConDa), in comparison with propofol and remifentanil.

Methods

Seventeen patients undergoing mechanical ventilation underwent sedation with sevoflurane delivered with AnaConDa (phase SevAn), preceded and followed by sedation with propofol and remifentanil (phases ProRe1, ProRe2), with the same sedation targets.

Results

With both strategies it was possible to achieve the sedation targets. Time required to sedate and awake patients was greater during SevAn than ProRe1: respectively, 3.3 ± 3.0 versus 8.9 ± 6.1 and 7.47 ± 5.05 versus 16.3 ± 11.4 min. During SevAn the PaCO2 and minute ventilation increased. Hemodynamics was stable between ProRe1 and SevAn, except for an increase in heart rate in the SevAn phase. Environmental pollution from sevoflurane was within the safety limits.

Conclusions

Sevoflurane can be effectively and safely used for short-term sedation of ICU patients with stable hemodynamic conditions.

Keywords

Volatile anestheticsSevofluraneSedationAnesthetic conserving deviceIntensive care unitMechanical ventilation

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Maurizio Migliari
    • 1
  • Giacomo Bellani
    • 1
    • 2
  • Roberto Rona
    • 1
  • Stefano Isgrò
    • 1
    • 2
  • Beatrice Vergnano
    • 1
    • 2
  • Tommaso Mauri
    • 1
    • 2
  • Nicolò Patroniti
    • 1
    • 2
  • Antonio Pesenti
    • 1
    • 2
  • Giuseppe Foti
    • 1
  1. 1.Department of Perioperative Medicine and Intensive CareSan Gerardo HospitalMonza (MI)Italy
  2. 2.Department of Experimental Medicine (DIMS)University of Milan-BicoccaMonza (MI)Italy