Intensive Care Medicine

, Volume 35, Issue 5, pp 796–809

Depression in general intensive care unit survivors: a systematic review

Authors

    • Department of Psychiatry and Behavioral SciencesHarborview Medical Center, University of Washington School of Medicine
  • Jeneen M. Gifford
    • Department of MedicineJohns Hopkins University School of Medicine
  • Sanjay V. Desai
    • Department of Pulmonary/Critical CareWashington Hospital Center
  • O. Joseph Bienvenu
    • Department of Psychiatry and Behavioral SciencesJohns Hopkins University School of Medicine
  • Dale M. Needham
    • Division of Pulmonary, Critical Care MedicineJohns Hopkins University School of Medicine
Review

DOI: 10.1007/s00134-009-1396-5

Cite this article as:
Davydow, D.S., Gifford, J.M., Desai, S.V. et al. Intensive Care Med (2009) 35: 796. doi:10.1007/s00134-009-1396-5

Abstract

Purpose

To critically review data on the prevalence of depressive symptoms in general intensive care unit (ICU) survivors, risk factors for these symptoms, and their impact on health-related quality of life (HRQOL).

Methods

We conducted a systematic review using Medline, EMBASE, Cochrane Library, CINAHL, PsycINFO, and a hand-search of 13 journals.

Results

Fourteen studies were eligible. The median point prevalence of “clinically significant” depressive symptoms was 28% (total n = 1,213). Neither sex nor age were consistent risk factors for post-ICU depression, and severity of illness at ICU admission was consistently not a risk factor. Early post-ICU depressive symptoms were a strong risk factor for subsequent depressive symptoms. Post-ICU depressive symptoms were associated with substantially lower HRQOL.

Conclusions

Depressive symptoms are common in general ICU survivors and negatively impact HRQOL. Future studies should address how factors related to individual patients, critical illness and post-ICU recovery are associated with depression in ICU survivors.

Keywords

DepressionCritical careRisk factorsQuality of lifeOutcome assessment (health care)

Abbreviation

ICU

Intensive care unit

Copyright information

© Springer-Verlag 2009