, Volume 34, Issue 1 Supplement, pp 93-180,
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Date: 08 Aug 2008

21st ESICM Annual Congress

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0352

Effect of CSF from Subarachnoid Hemorrhage-Patients with or Without Vasospasm on Endothelin-1 Sensitivity and Production on Isolated Rat Basilar Artery

B. Assenzio*1, E. L. Martin1, E. Stankevicius2, U. Simonsen2, I. Mastromauro1, S. Viberti1, M. M. Fontanella3, R. Boccaletti3, A. Ducati3, L. Mascia1

1Department of Anaesthesiology and Critical Care, University of Turin, Turin, Italy,

2Department of Pharmacology, Aarhus University, Aarhus, Denmark, 3Department of Neuroscience, University of Turin, Turin, Italy

Introduction

After subarachnoid hemorrhage (SAH) the presence of breakdown blood products is considered the initial trigger of vasospasm; however the subsequent pathogenic mechanisms remain unclear. The aims of this study were to: 1) compare the response to endothelin-1 (ET1) on isolated cerebral vessel incubated for 24 hours with CSF collected from patients with or without vasospasm, and 2) quantify ET1 production during incubation with CSF.

Methods

CSF was collected daily from pati ...